Fig. 2

Indications for bone marrow aspiration and pathological: Megakaryocyte depletion, one or fewer megakaryocytes per 5 to 10 low-power fields on bone marrow examination [15] Other, suspicion of tuberculosis (N=5), undetermined (N=5); Reactive bone marrow changes, non-specific bone marrow modifications associated with acute inflammation including hypercellularity, an increased myeloid-to-erythroid ratio with a large number of myeloid precursors and mature segmented neutrophils, with or without megakaryocyte hyperplasia, monocytosis and a slight increase in normal plasmocytes [14]; Vitamin B12/folate deficiency -like features, cytological signs classically associated with vitamin B12/folate deficiency including hypersegmented neutrophil granulocytes, giant metamyelocytes, erythroid asynchronism maturation