Authors, year | Country | Design Data source | Settings | Age | Incidence/prevalence | Mortality |
---|---|---|---|---|---|---|
Watson et al. 2003 [1] | USA 7 states | Retrospective Hospital discharge database | ICD-9a coding & modified Angus criteria 1995 | ≤19 years | Incidence 0.56 per 1000 population (1995) | Hospital 10.3% |
Hartman et al. 2013 [14] | USA 7 states | Retrospective Hospital discharge database | ICD-9a coding & modified Angus criteria 1995, 2000, 2005 | ≤19 years | Incidence 0.89 per 1000 population (2005) | Hospital 8.9% (2005) |
Ruth et al. 2014 [17] | USA 43 PICUs | Retrospective PHISb database | ICD-9a coding & modified Angus criteria 2004–2012 | ≤18 years | Prevalence 6.2% (2004) to 7.7% (2012) | Hospital 14.4%; 18.9% (2004) to 12.0% (2012) |
Wolfler et at. 2008 [23] | Italia 15 PICUs | Prospective | Proulx’s criteriac 2004–2005 | ≤16 years | Incidence Severe sepsis 1.6% Septic shock 2.1% | ICU Severe sepsis 17.7% Septic shockd 50.8% |
Shime et al. 2011 [22] | Japan 9 PICUs | Prospective | Severe sepsis | ≤15 years | Prevalence 1.4% | 28-day 18.9% |
Schlapbach et al. 2015 [18] | Australia/New Zealand 9 PICUs & 22 mixed ICUs | Retrospective dANZPIC registry | Invasive infection, sepsis, septic shock 2002–2013 | <16 years | Prevalence Invasive infection 6.9% Sepsis 2.9% Septic shock 2.1% | ICU Invasive infection 3.9% Sepsis 5.6% Septic shock 17.0% |
Weiss et al. 2015 (SPROUT) [19] | 26 countries worldwide 128 PICUs | Point prevalence | Severe sepsis 5 days, 2013–2014 | <18 years | Prevalence 8.2% | eICU 23% eHospital 24% |