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Table 3 Results of univariate analysis of factors of unexpected ICU transfer in patients with severe sepsis initially admitted to the wards

From: Unexpected intensive care transfer of admitted patients with severe sepsis

  Early escalation to ICU (n = 84) No escalation to ICU with 48 h (n = 274) p
Patient characteristics
 Age, years 58.5 (±18.3) 58.2 (±16.0) 0.872
 Sex, % male (n) 54% (45) 56% (153) 0.781
 Charlson co-morbidity index 3.44 (±2.11) 3.01 (±2.51) 0.125
 % immunocompromised (n) 67% (183) 58% (49) 0.152
 % from nursing home (n) 13% (36) 14% (12) 0.855
 % with active malignancy 30% (82) 32% (27) 0.787
Infection site,% (n)    0.03
 Abdominal 17% (14) 18% (49)  
 Cardiac 1% (1) 1% (3)  
 Central nervous system 0% (0) 2% (5)  
 Musculoskeletal 10% (8) 14% (39)  
 Genitourinary 21% (18) 34% (94)  
 Pulmonary 28% (24) 21% (56)  
 Other/unknown/multiple 23% (19) 10% (27)  
Vital signs
 Triage temperature (°C) 37.3 (±1.0) 38.1 (±5.5) 0.190
 Triage heart rate (BPM) 109 (±23) 110 (±24) 0.580
 Triage systolic blood pressure (mm Hg) 113 (±27) 111 (±24) 0.612
 Triage shock index (HR/SBP) 0.98 (±0.32) 1.03 (±0.28) 0.235
 Minimum SBP during ED stay (mm Hg) 93 (±21) 94 (±21) 0.809
 Maximal HR during ED stay (BPM) 120 (±24) 115 (±23) 0.072
 Maximal RR during stay (RPM) 25 (±6) 25 (±11) 0.975
Laboratory results
 Sodium (mEq/L) 134 (±5) 133 (±11) 0.600
 Creatinine (mg/dL) 1.70 (±1.5) 2.04 (±1.6) 0.692
 Bicarbonate (mEq/L) 22 (±4.7) 23 (±4.3) 0.218
 Lactate (mmol/L) 3.7 (±3.2) 2.6 (±1.8) 0.011
 % with lactate > = 4 mmol/L 28.1% 16.7% 0.039
 White count (×109/L) 13.2 (±8.4) 11.3 (7.8) 0.051
Interventions
 Time to antibiotics (min) 96.6 (±89.9) 113.1 (±86.7) 0.136
 Fluids administered in 1st 6 h (mL/kg) 35.7 (±18.5) 32.4 (±19.0) 0.167
Temporal impact
 Time in ED (min) 543 (±310) 646 (±411) 0.339
 % admission during weekday (n) 70% (192) 76% (64) 0.334
 % admission at night (n) 60% (50) 49% (134) 0.060
Mortality % (n) 25% (21) 8% (22) <0.005