Table 1 Recommendations in the related guidelines

Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines.

2013

The Scientific Standardization Committee on DIC of the International Society on Thrombosis Haemostasis

Trauma patients who present with severe bleeding, characterized by a marked hyperfibrinolytic state could be treated with antifibrinolytic agents (moderate quality).

A practical guideline for the hematological management of major haemorrhage.

2015

British Committee for Standards in Haematology

Adult trauma patients with, or at risk of, major hemorrhage, should be given TXA as soon as possible after injury (grade 1A).

The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition.

2016

The pan-European, multidisciplinary Task Force for Advanced Bleeding Care in Trauma

TXA administration was recommended as early as possible to a trauma patient who is bleeding or at risk of significant hemorrhaging (grade 1A)

Consider administration of the first dose of TXA en route to the hospital (grade 2C)

Major trauma: assessment and initial management.

2016

National Clinical Guideline Centre

Use intravenous TXA as soon as possible in patients with major trauma and active or suspected active bleeding.

Do not use intravenous TXA more than 3 h after injury in patients with major trauma unless there is evidence of hyperfibrinolysis.