Fig. 6
From: Monitoring the coagulation status of trauma patients with viscoelastic devices
Display screen during measurement with a PL-chip in the T-TAS system. The left window shows the measurement conditions such as flow rate of blood and temperature in the simulated vessel. The status of blood flowing can be observed in the upper right window. The lower right window shows a graph presenting the time course of thrombus formation. Blood flowing in a simulated blood vessel taken by a microcamera can be observed in real time in the upper right window. The lower right window shows a graph presenting the time course of thrombus formation in which the horizontal axis is time and the vertical axis is the measured pressure. This graph allows us to observe the process of thrombus formation visually. The left window shows the measured numerical data and measurement conditions. Measurement conditions are the flow rate of blood flowing in the simulated vessel and the temperature in the vessel, and these flowing conditions can be set freely. Therefore, this device allows us to simulate thrombus formation in various blood vessels in the body. Another chip, the AR-chip, has a built-in simulated blood vessel in which the inner lumen is coated with collagen and tissue factor. After adding Ca++ in the simulated vessel, citrated whole blood is activated by the collagen and tissue factor. Then, a very firm thrombus is formed by activated platelets and coagulation factors. Therefore, the AR-chip enables us to assess the cooperative capacity of platelets and the coagulation system in thrombus formation