Table 1 Summary of trauma-induced coagulopathy (cited from [21])
From: Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview
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1 Physiological changes • Hemostasis and wound healing 2 Pathological changes • Endogenously induced primary pathologies o Disseminated intravascular coagulation (DIC) • Activation of coagulation • Insufficient anticoagulation mechanisms • Increased fibrin(ogen)olysis (early phase) • Suppression of fibrinolysis (late phase) • Consumption coagulopathy o Acute coagulopathy trauma-shock (ACOTS) • Activated protein C-mediated suppression of coagulation • Activated protein C-mediated increased fibrinolysis • Exogenously induced secondary pathologies that modify DIC and ACOTS o Anemia-induced coagulopathy o Hypothermia-induced coagulopathy o Acidosis-induced coagulopathy o Dilutional coagulopathy o Others |