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Table 1 Baseline characteristics of the patients

From: Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study

  Low CVP group n = 33 High CVP group n = 37 p value
Median (95 % CI) Median (95 % CI)
Age, year 72 (68–76) 67 (64–71) 0.07
Male, n(%) 20 (61) 26 (70) 0.46
Body mass index, kg/m2 22 (20–23) 23 (21–24) 0.37
Systolic blood pressure, mmHg 99 (90–106) 92 (84–99) 0.22
Diastolic blood pressure, mmHg 50 (47–53) 48 (44–51) 0.30
Mean blood pressure, mmHg 66 (62–70) 62 (59–66) 0.17
Dopamine infusion rate, μg/kg/min 5.0 (3.5–6.6) 5.8 (4.4–7.3) 0.45
Noradrenaline infusion rate, μg/kg/min 0.12 (0.09–0.16) 0.16 (0.12–0.20) 0.20
Inotropic score 20 (15–25) 25 (21–30) 0.14
Vasopressor dependency index, mmHg−1 0.33 (0.23–0.45) 0.43 (0.34–0.53) 0.15
Heart rate, bpm 109 (103–116) 115 (109–121) 0.18
CVP, mmHg 8 (7–9) 15(14–16) <0.01
Cardiac output, L/min 4.6 (3.3–5.8) 5.7 (4.6–5.7) 0.18
Cardiac index, L/min/m2 2.8 (2.3–3.4) 3.3 (2.8–3.7) 0.23
Body temperture, °C 36.8 (36.4–37.2) 36.8 (36.4–37.2) 0.92
Arterial pH 7.36 (7.32–7.41) 7.27 (7.23–7.31) <0.01
Lactate, mmol/L 3.9 (2.6–5.3) 4.0 (2.9–5.2) 0.94
P/F ratio 220 (181–258) 168 (131–206) 0.06
PEEP, cmH2O 8 (6–10) 9 (7–11) 0.32
Renal replacement therapy, n(%) 13 (39) 23 (62) 0.06
Surgery, n(%) 21 (64) 17 (46) 0.16
Hemoglobin, g/dL 10.4 (9.7–11.1) 10.3 (9.6–11.0) 0.78
Platelet count, ×109/L 111 (87–134) 81 (59–104) 0.08
CRP, mg/dL 17.7 (11.4–24.0) 17.6 (11.6–23.5) 0.97
Total Bilirubin, mg/dL 1.7 (0.2–3.1) 3.6 (2.2–5.0) 0.06
Total Protein, mg/dL 4.9 (4.5–5.3) 4.6 (4.2–4.9) 0.17
APACHE II score 26 (25–28) 28 (26–30) 0.23
SOFA score 12 (11–13) 14 (13–15) 0.01
 SOFA cardiovascular 3.5 (3.3–3.7) 3.7 (3.5–3.9) 0.29
 SOFA renal 1.9 (1.4–2.4) 2.3 (1.8–2.8) 0.22
 SOFA hematological 1.6 (1.2–2.0) 2.1 (1.8–2.5) 0.05
 SOFA respiratory 2.4 (1.9–2.8) 2.8 (2.4–3.2) 0.15
 SOFA liver 0.8 (0.4–1.2) 1.4 (1.0–1.7) 0.04
 SOFA central nerve system 2.0 (1.6–2.5) 2.0 (1.5–2.4) 0.83
Time from ICU admission until starting PMX-DHP, min 441 (98–802) 829 (498–1159) 0.11
PMX-DHP duration, min 354 (249–458) 366 (263–469) 0.97
Total fluid dosage from ICU admission until starting PMX-DHP, ml 2970 (1200–4760) 3212 (1223–5203) 0.86
  1. APACHE Acute Physiologic and Chronic Health Evaluation, CRP c-reactive protein, CVP central venous pressure, ICU intensive care unit, PEEP positive end-expiratory pressure, P/F ratio arterial oxygen tension/fractional inspired oxygen ratio PMX-DHP direct hemoperfusion with polymyxin B-immobilized fiber column, SOFA Sequential Organ Failure Assessment