Table 1 Baseline characteristics of the patients
Low CVP group n = 33 | High CVP group n = 37 | p value | |
|---|---|---|---|
Median (95 % CI) | Median (95 % CI) | ||
Age, year | 72 (68–76) | 67 (64–71) | 0.07 |
Male, n(%) | 20 (61) | 26 (70) | 0.46 |
Body mass index, kg/m2 | 22 (20–23) | 23 (21–24) | 0.37 |
Systolic blood pressure, mmHg | 99 (90–106) | 92 (84–99) | 0.22 |
Diastolic blood pressure, mmHg | 50 (47–53) | 48 (44–51) | 0.30 |
Mean blood pressure, mmHg | 66 (62–70) | 62 (59–66) | 0.17 |
Dopamine infusion rate, μg/kg/min | 5.0 (3.5–6.6) | 5.8 (4.4–7.3) | 0.45 |
Noradrenaline infusion rate, μg/kg/min | 0.12 (0.09–0.16) | 0.16 (0.12–0.20) | 0.20 |
Inotropic score | 20 (15–25) | 25 (21–30) | 0.14 |
Vasopressor dependency index, mmHg−1 | 0.33 (0.23–0.45) | 0.43 (0.34–0.53) | 0.15 |
Heart rate, bpm | 109 (103–116) | 115 (109–121) | 0.18 |
CVP, mmHg | 8 (7–9) | 15(14–16) | <0.01 |
Cardiac output, L/min | 4.6 (3.3–5.8) | 5.7 (4.6–5.7) | 0.18 |
Cardiac index, L/min/m2 | 2.8 (2.3–3.4) | 3.3 (2.8–3.7) | 0.23 |
Body temperture, °C | 36.8 (36.4–37.2) | 36.8 (36.4–37.2) | 0.92 |
Arterial pH | 7.36 (7.32–7.41) | 7.27 (7.23–7.31) | <0.01 |
Lactate, mmol/L | 3.9 (2.6–5.3) | 4.0 (2.9–5.2) | 0.94 |
P/F ratio | 220 (181–258) | 168 (131–206) | 0.06 |
PEEP, cmH2O | 8 (6–10) | 9 (7–11) | 0.32 |
Renal replacement therapy, n(%) | 13 (39) | 23 (62) | 0.06 |
Surgery, n(%) | 21 (64) | 17 (46) | 0.16 |
Hemoglobin, g/dL | 10.4 (9.7–11.1) | 10.3 (9.6–11.0) | 0.78 |
Platelet count, ×109/L | 111 (87–134) | 81 (59–104) | 0.08 |
CRP, mg/dL | 17.7 (11.4–24.0) | 17.6 (11.6–23.5) | 0.97 |
Total Bilirubin, mg/dL | 1.7 (0.2–3.1) | 3.6 (2.2–5.0) | 0.06 |
Total Protein, mg/dL | 4.9 (4.5–5.3) | 4.6 (4.2–4.9) | 0.17 |
APACHE II score | 26 (25–28) | 28 (26–30) | 0.23 |
SOFA score | 12 (11–13) | 14 (13–15) | 0.01 |
SOFA cardiovascular | 3.5 (3.3–3.7) | 3.7 (3.5–3.9) | 0.29 |
SOFA renal | 1.9 (1.4–2.4) | 2.3 (1.8–2.8) | 0.22 |
SOFA hematological | 1.6 (1.2–2.0) | 2.1 (1.8–2.5) | 0.05 |
SOFA respiratory | 2.4 (1.9–2.8) | 2.8 (2.4–3.2) | 0.15 |
SOFA liver | 0.8 (0.4–1.2) | 1.4 (1.0–1.7) | 0.04 |
SOFA central nerve system | 2.0 (1.6–2.5) | 2.0 (1.5–2.4) | 0.83 |
Time from ICU admission until starting PMX-DHP, min | 441 (98–802) | 829 (498–1159) | 0.11 |
PMX-DHP duration, min | 354 (249–458) | 366 (263–469) | 0.97 |
Total fluid dosage from ICU admission until starting PMX-DHP, ml | 2970 (1200–4760) | 3212 (1223–5203) | 0.86 |