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Fig. 2 | Journal of Intensive Care

Fig. 2

From: Context-sensitive fluid therapy in critical illness

Fig. 2

a Effects of fluid filtration (J v) across capillaries on subglycocalyx albumin concentration. Albumin entering into the interstitium via a large pore (J s, solid arrow in black) diffuses backwards into the subglycocalyx space according to concentration gradients (i.e., upstream diffusion, dotted arrow in black). Fluid filtration across the endothelial glycocalyx (EG) layer dilutes albumin in the subglycocalyx space (i.e., downstream washout, dotted arrow in white). Cited from reference [17] with permission. ESL endothelial surface layer, P C , P i hydrostatic pressure in the capillary and interstitium, respectively, π c, π i, π g colloid osmotic pressure in the capillary, interstitium, and subglycocalyx space, respectively. b Effects of capillary hydrostatic pressure (P C) on albumin concentration along the endothelial glycocalyx (EG) layer. ESL endothelial surface layer, π i, π g colloid osmotic pressure in the interstitium and subglycocalyx space, respectively. Normal P C is approximately 25 cmH2O. Cited from reference [18] with permission

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