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Fig. 3 | Journal of Intensive Care

Fig. 3

From: RETRACTED ARTICLE: Brain injury following cardiac arrest: pathophysiology for neurocritical care

Fig. 3

Calcium overload and the calcineurin/cyclophilin D signal transduction pathway for the cell death induced after cerebral ischemia. Ischemia induces the loss of ATP-dependent ion homeostasis and leads to an increase in intracellular Na+ and extracellular K+. Eventually, the cells undergo depolarization. As a result, excessive Ca2+ influx due to the activation of voltage-sensitive calcium channels, NMDA, and AMPA receptors activates numerous signal transduction cascades, particularly the calcineurin/cyclophilin D signal transduction pathway. This eventually induces the MPT, leading to mitochondrial dysfunction

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