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Table 1 Patient characteristics

From: Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study

Variable

All cases

Survivor

Non-survivor

P value

n

207

123

84

 

Age (years)

66.7 ± 16.8

63.9 ± 17.6

70.7 ± 14.9

0.004

Male

134 (64.7%)

77 (62.6%)

57 (67.9%)

0.437

Sepsis, yes

128 (61.8%)

70 (56.9%)

58 (69.0%)

0.078

APACHE II score

23.4 ± 8.1

21.9 ± 7.8

25.6 ± 8.1

0.001

SOFA score

10.7 ± 3.6

10.0 ± 3.2

11.8 ± 3.7

<0.001

PaO2/FiO2 ratio (mmHg)

150.5 ± 70.9

155.8 ± 70.2

142.8 ± 71.6

0.195

Lung injury score

2.3 ± 0.6

2.3 ± 0.6

2.3 ± 0.6

0.702

28-day mortality rate

84 (40.6%)

0 (0%)

84 (100%)

-

Day 0

    

 EVLWI (mL/kg)

18.5 ± 6.8

18.5 ± 6.9

18.5 ± 6.7

0.981

 GEDVI (mL/m2)

816.8 ± 205.7

823.0 ± 211.8

807.5 ± 197.2

0.595

 SVV (%)

15.7 ± 6.9

15.4 ± 7.3

16.1 ± 6.4

0.472

 CVP (mmHg)

10.2 ± 5.3

9.8 ± 4.9

10.7 ± 5.8

0.221

 CI (L/min · m2)

3.5 ± 1.3

3.6 ± 1.2

3.3 ± 1.3

0.171

 SVRI (dyn · s · cm−5 · m2)

1,805 ± 866

1,716 ± 707

1,932 ± 1,043

0.083

 ALB (g/dL)

2.6 ± 0.7

2.6 ± 0.7

2.6 ± 0.7

0.509

 OSM (mOsm/L)

304.7 ± 16.7

303.5 ± 15.6

306.4 ± 18.1

0.227

 PEEP (cmH2O)

8.7 ± 4.7

8.8 ± 4.7

8.5 ± 4.8

0.720

Day 1

    

 EVLWI (mL/kg)

17.7 ± 7.4

17.3 ± 7.2

18.4 ± 7.8

0.280

 GEDVI (mL/m2)

821.4 ± 222.5

828.8 ± 222.3

810.1 ± 223.7

0.561

 SVV (%)

14.2 ± 7.6

14.0 ± 8.7

14.6 ± 5.7

0.581

 CVP (mmHg)

10.6 ± 4.8

9.9 ± 4.4

11.7 ± 5.2

0.007

 CI (L/min · m2)

3.5 ± 1.2

3.6 ± 1.1

3.3 ± 1.3

0.119

 SVRI (dyn · s · cm−5 · m2)

1,880 ± 852

1,865 ± 873

1,902 ± 824

0.767

 ALB (g/dL)

2.5 ± 0.6

2.5 ± 0.6

2.4 ± 0.6

0.304

 PEEP (cmH2O)

8.9 ± 5.2

9.0 ± 5.1

8.9 ± 5.5

0.934

Day 2

    

 EVLWI (mL/kg)

16.4 ± 7.4

15.7 ± 6.4

17.7 ± 8.8

0.077

 GEDVI (mL/m2)

858.3 ± 238.2

844.7 ± 237.2

880.2 ± 239.7

0.315

 SVV (%)

12.4 ± 5.9

10.9 ± 5.5

14.7 ± 5.8

<0.001

 CVP (mmHg)

10.4 ± 5.0

9.6 ± 4.3

11.7 ± 5.7

0.004

 CI (L/min · m2)

3.7 ± 1.3

3.7 ± 1.3

3.7 ± 1.3

0.920

 SVRI (dyn · s · cm−5 · m2)

1,791 ± 733

1,791 ± 733

1,791 ± 733

0.977

 ALB (g/dL)

2.5 ± 0.6

2.5 ± 0.6

2.5 ± 0.6

0.880

 PEEP (cmH2O)

8.5 ± 5.0

8.5 ± 4.9

8.5 ± 5.3

0.947

  1. Values are means ± standard deviation or n (%). P value: survivor vs. non-survivor. The italicized values are statistically significant. APACHE acute physiology and chronic health evaluation, SOFA sequential organ failure assessment, EVLWI extravascular lung water index, GEDVI global end-diastolic volume index, SVV stroke volume variation, CVP central venous pressure, CI cardiac index, SVRI systemic vascular resistance index, ALB serum albumin, OSM calculated serum osmotic pressure (OSM = 2(Na + K) + BS / 18 + BUN / 2.8, where Na = sodium concentration (mmol/L), K = potassium concentration (mmol/L), BS = blood sugar concentration (mg/dL), and BUN = blood urea nitrogen concentration (mg/dL)), PEEP positive end-expiratory pressure.
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Journal of Intensive Care

ISSN: 2052-0492