Table 1 Differences in recommendations among three guidelines from BCSH, JSTH, and SISET and harmonized ISTH/SSC guidance
| Â | BCSH | JSTH | SISET | ISTH/SSC |
|---|---|---|---|---|
Scoring system for DIC | R; grade C | Ra | R; grade C | R; high quality |
Single test analysis for DIC | NR | NRa | NR; grade D | R high quality |
Treatment of underlying disease | R; grade C | R; consensus | R; cornerstone | R; moderate quality |
Platelet concentration | R; grade C | R; consensus | R; grade D | R; low quality |
FFP | R; grade C | R; consensus | R; grade D | R; low quality |
Fibrinogen, cryoprecipitate | R; grade C | Disregard | R; grade D | R; low quality |
FVIIa | Disregard | Disregard | NR; grade D | NM |
UFH (treatment) | R; grade C | R; level C | NR; grade D | R; low quality |
UFH (prophylaxis for VTE) | R; grade A | Disregard | R | R; high quality |
LMWH | Disregard | R; level B2 | R; grade D | Preferred to UFH |
Heparin sulfate | Disregard | R; level C | Â | NM |
Synthetic protease | Disregard | R; level B2 | NR; grade D | NM |
rhAPC | R; grade A | Disregard | R; grade D | Need for further Ed from RCT |
AT | NR; grade A | R; B1 | NR; grade D | Need for further Ed from RCT |
rhTM | Disregard | Disregard | NR; grade B | Need for further Ed from RCT |
Antifibrinolytic agents | R; grade C | NR; level D | Â | R; low quality |
Plasma exchange | Disregard | Disregard | NR; grade D | NM |