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Table 1 Differences in recommendations among three guidelines from BCSH, JSTH, and SISET and harmonized ISTH/SSC guidance

From: Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines

  BCSH JSTH SISET ISTH/SSC
Scoring system for DIC R; grade C Ra R; grade C R; high quality
Single test analysis for DIC NR NRa NR; grade D R high quality
Treatment of underlying disease R; grade C R; consensus R; cornerstone R; moderate quality
Platelet concentration R; grade C R; consensus R; grade D R; low quality
FFP R; grade C R; consensus R; grade D R; low quality
Fibrinogen, cryoprecipitate R; grade C Disregard R; grade D R; low quality
FVIIa Disregard Disregard NR; grade D NM
UFH (treatment) R; grade C R; level C NR; grade D R; low quality
UFH (prophylaxis for VTE) R; grade A Disregard R R; high quality
LMWH Disregard R; level B2 R; grade D Preferred to UFH
Heparin sulfate Disregard R; level C   NM
Synthetic protease Disregard R; level B2 NR; grade D NM
rhAPC R; grade A Disregard R; grade D Need for further Ed from RCT
AT NR; grade A R; B1 NR; grade D Need for further Ed from RCT
rhTM Disregard Disregard NR; grade B Need for further Ed from RCT
Antifibrinolytic agents R; grade C NR; level D   R; low quality
Plasma exchange Disregard Disregard NR; grade D NM
  1. R, recommendation; NR, not recommendation; Ra, suggestive recommendation; NM, not mention; Ed, evidence; FFP, fresh frozen plasma; PCC, FVIIa, activated coagulation factor VII; UFH, unfractionated heparin; LMWH, low molecular weight heparin; rh, recombinant human; APC, activated protein C; AT, antithrombin; TM, thrombomodulin; RCT, randomized control trial.