Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock

Table 1 Patient characteristics ( n = 79)

	S group (n= 42)^a	H group (n= 37)^a	P value
Age (years)	66.7 ± 2.0	67.7 ± 2.2	0.744
Gender (male/female)	21/21	25/12	0.057
Body height (cm)	159.9 ± 1.4	161.4 ± 1.6	0.465
Body weight (kg)	54.6 ± 2.0	53.5 ± 2.0	0.699
APACHE II score	25.5 (13–39)	27 (8–43)	0.115
APACHE II(−GCS)	17 (8–29)	17 (8–32)	0.936
SOFA score	11 (3–15)	10 (4–17)	0.462
SOFA(−GCS)	8 (2–14)	6 (1–13)	0.117
Clinical stratification (sever sepsis/septic shock)	4/38	5/32	0.418
Source of infection
Generalized peritonitis	15 (35.7%)	13 (35.1%)
Pneumonia	4 (9.5%)	6 (16.2%)
Urinary tract	6 (14.3%)	2 (5.4%)
Bacteremia	4 (9.5%)	3 (8.1%)
Cellulitis	2 (4.8%)	2 (5.4%)
Biliary tract	2 (4.8%)	1 (2.7%)
Others	5 (11.9%)	6 (16.2%)
Unknown	4 (9.5%)	4 (10.8%)

^aPatients in the S group were administered a standard IVIG dose of 5 g/day for 3 days; patients in the H group were administered a single high dose of 15 g/day for 1 day. Continuous variables: mean ± SEM; ordinal variables: median (interquartile); nominal variables: percentage. APACHE II, Acute Physiology and Chronic Health Evaluation II; APACHE II(−GCS), APACHE II without Glasgow Coma Scale; SOFA, Sequential Organ Failure Assessment; SOFA(−GCS), SOFA without Glasgow Coma Scale.

ISSN: 2052-0492