Figure 7
From: Neutrophil cell death in response to infection and its relation to coagulation
NETosis and microthrombus formation in sepsis. Microbes activate the neutrophils. Activated neutrophils activate platelets and the coagulation system by expelling microparticles, nuclear components, and granular proteins. At the same time, neutrophils accumulate and adhere to the endothelium in collaboration with platelets during sepsis. There, neutrophils expel NETs that kill bacteria and activate the coagulation system. NETs serve as a scaffold for thrombus formation. Thrombi substantially lead to microcirculatory damage and then organ dysfunction in sepsis.