From: Lacosamide dosing in patients receiving continuous renal replacement therapy
Selected dosing regimens | Average PTA (%) (AUC of 143–231 mg*h/L) | ||||||
---|---|---|---|---|---|---|---|
CVVHD | CVVH | ||||||
Effluent rates (mL/kg/h) | |||||||
20 | 25 | 35 | 20 | 25 | 35 | ||
250 mg q 12 h | In TR | 71.90 | 71.93 | 52.32 | 70.14 | 75.49 | 74.00 |
Above TR | 18.06 | 9.37 | 1.60 | 24.64 | 15.31 | 5.13 | |
Below TR | 10.04 | 18.70 | 46.08 | 5.22 | 9.20 | 20.87 | |
300 mg LD, followed by 250 mg q 12 h | In TR | 70.53 | 73.44 | 57.14 | 64.84 | 72.94 | 77.09 |
Above TR | 22.65 | 11.72 | 3.00 | 31.80 | 20.58 | 7.39 | |
Below TR | 6.82 | 14.84 | 39.86 | 3.36 | 6.48 | 15.52 | |
350 mg LD, followed by 250 mg q 12 h | In TR | 67.16 | 72.61 | 63.33 | 60.99 | 69.98 | 78.93 |
Above TR | 28.17 | 16.44 | 3.88 | 37.04 | 25.78 | 10.80 | |
Below TR | 4.67 | 10.95 | 32.79 | 1.97 | 4.24 | 10.81 | |
300 mg q 12 h | In TR | 52.28 | 65.50 | 72.54 | 42.57 | 53.62 | 72.61 |
Above TR | 46.09 | 29.94 | 10.80 | 56.88 | 45.12 | 23.68 | |
Below TR | 1.63 | 4.56 | 16.66 | 0.55 | 1.26 | 3.71 | |
150 mg q 8 h | In TR | 67.47 | 56.92 | 31.77 | 73.26 | 70.15 | 53.87 |
Above TR | 6.24 | 2.64 | 0.22 | 9.81 | 5.11 | 1.08 | |
Below TR | 26.29 | 40.44 | 68.01 | 16.93 | 24.74 | 45.05 | |
200 mg LD, followed 150 mg q 8 h | In TR | 70.73 | 62.94 | 38.16 | 74.21 | 73.40 | 61.67 |
Above TR | 9.24 | 4.11 | 0.54 | 13.63 | 7.17 | 1.74 | |
Below TR | 20.03 | 32.59 | 61.30 | 12.16 | 19.43 | 36.59 | |
250 mg LD, followed by 150 mg q 8 h | In TR | 73.19 | 68.83 | 44.87 | 73.40 | 76.55 | 68.46 |
Above TR | 12.71 | 5.94 | 0.86 | 18.61 | 10.58 | 3.15 | |
Below TR | 14.10 | 25.23 | 54.27 | 7.99 | 12.87 | 28.39 | |
200 mg q 8 h | In TR | 57.77 | 67.63 | 70.65 | 48.40 | 58.49 | 73.77 |
Above TR | 39.75 | 26.31 | 9.00 | 50.56 | 39.89 | 20.76 | |
Below TR | 2.48 | 6.06 | 20.35 | 1.04 | 1.62 | 5.47 | |
250 mg LD, followed by 200 mg q 8 h | In TR | 51.86 | 64.79 | 72.84 | 42.07 | 53.85 | 70.94 |
Above TR | 46.73 | 30.92 | 11.03 | 57.35 | 45.03 | 25.26 | |
Below TR | 1.41 | 4.29 | 16.13 | 0.58 | 1.12 | 3.80 |