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Table 5 Univariate and multivariate analysis of clinical factors associated with 28-day mortality and day 28 clinical failure in propensity score-matched ICU patients with nosocomial pneumonia caused by CR-GNB

From: Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study

 

28-day mortalitya

Day 28 clinical failureb

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

aHR (95% CI)

P value

OR (95% CI)

P value

aOR (95% CI)

P value

Age

1.00 (0.98–1.01)

0.658

  

0.74 (0.99–1.03)

0.664

  

Male

1.20 (0.76–1.90)

0.438

  

1.11 (0.63–1.98)

0.642

  

BMI

0.93 (0.88–0.98)

0.010

0.93 (0.88–0.99)

0.014

0.90 (0.84–0.96)

0.003

0.90 (0.83–0.97)

0.005

CRAB

0.63 (0.37–1.09)

0.097

0.74 (0.43–1.29)

0.293

1.14 (0.53–2.46)

0.734

  

Medical ICU

0.91 (0.57–1.44)

0.683

  

1.06 (0.58–1.95)

0.842

  

Malignancies

1.19 (0.67–2.11)

0.562

  

1.23 (0.38–1.73)

0.171

  

Renal insufficiency

1.06 (0.56–2.00)

0.855

  

1.13 (0.66–3.74)

0.411

  

Chronic lung diseases

1.37 (0.81–2.31)

0.239

  

1.09 (0.81–3.56)

0.588

  

Diabetes

0.70 (0.44–1.10)

0.123

  

1.45 (0.34–1.07)

0.041

0.68 (0.36–1.26)

0.215

APACHE II scorec

1.02 (0.99–1.05)

0.194

  

1.02 (0.98–1.06)

0.348

  

SOFA scored

1.14 (1.08–1.21)

< 0.001

1.12 (1.06–1.19)

< 0.001

1.19 (1.09–1.30)

< 0.001

1.19 (1.09–1.31)

< 0.001

PF ratio ≤ 200e

1.29 (0.83–2.02)

0.263

  

1.59 (0.88–2.9)

0.128

  

Septic shocke

1.29 (0.75–2.23)

0.358

  

1.44 (0.68–3.05)

0.347

  

Dialysise

1.25 (0.69–2.26)

0.464

  

1.69 (0.71–3.99)

0.233

  

Albumin ≤ 3 mg/dLd

0.99 (0.64–1.53)

0.954

  

0.84 (0.48–1.46)

0.530

  

Sulbactam susceptible

0.94 (0.58–1.52)

0.798

  

0.57 (0.3–1.08)

0.083

0.66 (0.33–1.31)

0.236

Colistin susceptible

1.02 (0.51–2.05)

0.946

  

1.20 (0.07–19.38)

0.900

  

Add-on tigecycline

0.44 (0.28–0.69)

< 0.001

0.47 (0.30–0.74)

0.001

0.51 (0.29–0.89)

0.017

0.52 (0.28–0.95)

0.032

  1. APACHE II Acute Physiology and Chronic Health Evaluation II, CRAB carbapenem-resistant Acinetobacter baumannii, ICU intensive care unit, PF ratio PaO2/FiO2 ratio, SOFA Sequential Organ Failure Assessment
  2. aAdjusted hazard ratio (aHR) and 95% confidence interval (CI) were derived from Cox regression analysis
  3. bAdjusted odds ratio (aOR) and 95%CI were derived from logistic regression analysis
  4. cObtaind on ICU admission date
  5. dObtained on pneumonia index date
  6. ePresence of organ dysfunction on the pneumonia index date
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Journal of Intensive Care

ISSN: 2052-0492