Table 2 C. auris virulence and resistance factors
From: Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
Virulence genes encoding for:  Hemolysin, secreted aspartyl proteinases, secreted lipases, phosphatases, mannosyl transferases, phospholipase, integrins, adhesins, Zn(II) 2 cys 6 transcription factor (strain-specif degree of activity) | |
Resistance genes: Azoles resistance  Transport proteins and efflux pumps (ATP-binding cassette ABC; major facilitator superfamilies MFS; upregulation of CDR1, CDR2, MDR1)  ERG 11 mutations (substitutions Y132F, K143R, and F126T) and ERG 11 upregulation Echinocandin resistance  FKS1/2 (encoding echinocandin drug target 1,3-beta-glucan synthase) | |
Adherence to surfaces and plastic materials (e.g., catheters) | |
Biofilm formation | |
Cellular morphology (aggregating and non-aggregating forms) | |
Rudimentary pseudohyphae formation |