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Table 4 Uni- and multivariate Cox regression analyses for CT-proET-1 levels at ICU admission to predict overall mortality

From: C-terminal proendothelin-1 (CT-proET-1) is associated with organ failure and predicts mortality in critically ill patients

 

Unadjusted HR (95%-CI)

p

Adjusted HR (95%-CI)

p

CT-proET-1 > 74 pmol/L

2.731 (1.535–4.858)

0.001

2.193 (1.209–3.975)

0.01

Creatinine (per mg/dL)

1.034 (0.946–1.129)

0.461

n.s.

CRP (per mg/L)

1.002 (0.999–1.006)

0.129

n.s.

Bilirubin (per mg/dL)

1.16 (0.935–1.16)

0.176

n.s.

Prothrombin time (per %)

0.99 (0.979–1)

0.052

n.s.

Lactate (per mmol/L)

1.082 (0.949–1.234)

0.239

n.s.

Age (per year)

1.036 (1.014–1.059)

<0.001

1.028 (1.005–1.051)

0.04

  1. Variables with a univariate p < 0.25 were included in the multivariate model
  2. Abbreviations: 95%-CI 95% confidence-interval, CRP C-reactive protein, CT-proET-1 C-terminal proendothelin-1, n.s. not significant