From: Trauma-induced coagulopathy and critical bleeding: the role of plasma and platelet transfusion
Authors | Year | Patients | FFP/RBC ratio | Results |
---|---|---|---|---|
Borgman | 2007 | 246 | <1:4 vs. 1:4—1:2 vs. >1:2 | Improved in-hospital survival in highest ratio group (OR 8.6, CI 2.1–35.2) |
Maegele | 2008 | 713 | <0.9 vs. 0.9—1.1 vs. >1.1 | Decreased 30-day mortality in highest ratio group (24 vs. 46%, p < 0.001) |
Duchesne | 2008 | 135 | <1:2 vs. >1:2 | Increased mortality in low-ratio group (RR 18.9; CI 6.3–56.4) |
Holcomb | 2008 | 466 | <1:2 vs. ≥1:2 | Improved 30-day survival in high plasma transfusion group (73 vs. 43%, p < 0.001) |
Zink | 2009 | 466 | <1:4 vs. 1:4—1:1 vs. ≥1:1 | Decreased in-hospital mortality in high plasma transfusion groups (ARR of 29%) |
Sperry | 2008 | 415 | <1:1.5 vs. ≥1:1.5 | High plasma ratio is independently associated with lower mortality (HR 0.48, CI 0.3–0.8) |
Gunter | 2008 | 259 | <2:3 vs. ≥2:3 | Decreased 30-day morality in high plasma transfusion groups |
Kashuk | 2008 | 133 | 1:1 vs. 1:2 vs. 1:3 vs. 1:4 vs. ≥1:5 | The lowest predicted mortality probability correlates with a plasma/red cell ratio of 1:2 and 1:3. |
Teixeira | 2009 | 383 | ≤1:8 vs. 1:8—1:3 vs. 1:3—1:2 vs. >1:2 | Linear correlation between survival and plasma transfusion ratio. No survival advantage after plasma transfusion ratio reaches 1:3 |