Fig. 6

Effect of mannitol administration on patient with intracranial hypertension. A male in his 60s suffered traumatic brain injury. Brain CT scan demonstrated cerebral contusion. Mannitol administration is a potentially effective volume replacement method in the early phase and can stimulate the vasoconstriction cascade. SjO₂ values gradually increase after mannitol administration. This phenomenon is likely caused by the volume expansion effect of mannitol, which could stimulate the vasoconstriction cascade leading to decreased CBV. Mannitol will then work as a hyperosmotic diuretic agent at the late phase resulting in decreased ICP and increased CPP. Resp. respiration, SAP systemic arterial pressure, ICP intracranial pressure, SjO ₂ jugular bulb oxygen saturation, CBV cerebral blood volume, CPP cerebral perfusion pressure, Mannitol mannitol administration. Data were obtained from brain injury patient monitored at our hospital in the 1990s