Variable | Overall (n = 40) | Survivors (n = 32) | Non-survivors (n = 8) |
---|---|---|---|
Demographic data | |||
Age (years), mean (SD) | 55.5 (15.9) | 53 (16.4) | 65 (9.8)* |
Male, n (%) | 27 (67.5) | 21 (65.6) | 6 (75.0) |
Severity of illness | |||
APACHE II score at day 1, median (IQR 25–75) | 17 (12–21) | 16 (12–20) | 22 (18–34)** |
SOFA score at day 1, median (IQR 25–75) | 4 (3–5) | 4 (3–5) | 4 (3–8) |
Major ATS criteria, median (IQR 25–75) | 28 (70) | 20 (62.5) | 8 (100)** |
Invasive mechanical ventilation, n (%) | 21 (52.5) | 13 (40.6) | 8 (100)*** |
Severe sepsis, n (%) | 18 (44.5) | 17 (53.1) | 1 (12.5) |
Septic shock, n (%) | 22 (55.5) | 15 (46.9) | 7 (87.5)* |
Mean comorbidities, n (%) | |||
Tobacco use | 3 (8.6) | 3 (10.7) | 0 |
Chronic obstructive pulmonary disease | 12 (33.3) | 10 (34.3) | 2 (28.6) |
Cardiac disease | 8 (20) | 6 (18.7) | 2 (28.6) |
Diabetes mellitus | 7 (20) | 5 (17.9) | 2 (28.6) |
Severe liver disease | 1 (2.9) | 0 | 1 (14.3) |
Hemodynamic data, median (IQR 25–75) | |||
Heart rate, b/min | 105 (86–114) | 105 (87–114) | 105 (85–113) |
Heart rate at 24 h | 90 (77–100) | 92 (79–103) | 85 (70–99) |
Mean arterial pressure, mmHg | 79 (71–94) | 78 (72–98) | 80 (69–88) |
Mean arterial pressure at 24 h | 79 (70–93) | 76 (70–96) | 79 (71–90) |
Central venous pressure, mmHg | 11 (9–15) | 11 (8–15) | 11 (10–14) |
Central venous pressure at 24 h | 13 (13–16) | 11 (7–16) | 14 (12–15) |
Mixed venous oxygen saturation, %a | 76 (70–79) | 76 (69–79) | 74 (74) |
Mixed venous oxygen saturation at 24 ha | 70 (68–83) | 70 (68–80) | 80 (70–91) |
Biochemical data, mean (SD) | |||
Baseline serum lactate, mM/L | 3.0 (3.1) | 2.5 (1.6) | 4.8 (6.1) |
Serum lactate at 24 h | 2.0 (2.2) | 1.4 (0.6) | 3.9 (4.0) |
Baseline base deficit | −3.5 (5.2) | −3.6 (5.4) | −2.7 (4.3) |
Base deficit at 24 h | −2.3 (4.1) | −1.9 (4.1) | −3.4 (4.2) |
Baseline haemoglobin levels, mg % | 11.9 (1.8) | 12.1 (1.9) | 11.2 (1.1) |
Haemoglobin levels at 24 h | 10.6 (1.7) | 10.6 (1.9) | 10.4 (1.1) |
Baseline serum glucose, mg % | 166 (74.7) | 158 (75.3) | 197 (66.8) |
Serum glucose at 24 h | 152 (75.6) | 144 (79.4) | 177 (58.7) |
Baseline arterial pH | 7.34 (0.1) | 7.40 (0.1) | 7.34 (0.3) |
Arterial pH at 24 h | 7.36 (0.07) | 7.30 (0.07) | 7.32 (0.1) |
Baseline serum creatinine, mg % | 1.40 (0.9) | 1.38 (1.03) | 1.41 (0.8) |
Serum creatinine at 24 h | 1.1 (0.59) | 0.9 (0.4) | 1.5 (0.9) |
rSO2 brachioradialsis | |||
Baseline rSO2, mean (SD) | 62.9 (10.7) | 68 (61–72) | 46 (43–57)*** |
rSO2 at 24 h, mean (SD) | 65.4 (12.3) | 69 (60–76) | 52 (41–57)*** |
Baseline rSO2 < 60, n (%) | 14 (35) | 7 (21.9) | 7 (87.5)*** |
rSO2 < 60 at 24 h, n (%) | 6 (15.8) | 4 (12.5) | 7 (87.5)*** |
Therapy, mean (SD) | |||
Norepinephrine at baseline μg/kg/min | 0.35 (0.26) | 0.40 (0.14) | 0.29 (0.36) |
Norepinephrine at 24 h, μg/kg/min | 0.35 (0.29) | 0.22 (0.28) | 0.52 (0.23)* |
Fluid balance at 24 h, mL | 1650 (1350) | 1470 (800) | 2300 (2500) |
ICU length of stay | |||
Median IQR 25–75 % | 18 (11–30) | 18 (11–31) | 24 (8–30) |