Fig. 4

The therapeutic target of anticoagulant. The most popular anticoagulants worldwide are heparins, meanwhile, antithrombin and recombinant thrombomodulin are popularly used for disseminated intravascular coagulation (DIC) in Japan. For more than a decade, it has been reported that anticoagulant therapy is effective only for patients with coagulation disorder, and recent studies have shown that sepsis-associated DIC with high disease severity is the optimal target