Fig. 1

The initiation and progression of thromboinflammation in sepsis. The inflammation and host responses to infection induce coagulation disorder in sepsis. Although coagulation disorder is a part of host defense, excess coagulation disorder can be harmful to the host. Disseminated intravascular coagulation (DIC) is a systemic coagulation disorder that can cause the disturbance of tissue malcirculation and subsequent organ dysfunction. Sepsis-induced coagulopathy (SIC) is an early phase of DIC and a potential target of anticoagulant therapy. The advanced stage of DIC is defined as overt DIC and potentially the target of supplementation therapy