Table 4 Association of high-shear blood viscosity and respiratory organ support-free days up to day 21 according to subgroups
From: Association of blood viscosity and device-free days among hospitalized patients with COVID-19
HSBV quartile 1 (Lowest) | HSBV quartile 2 | HSBV quartile 3 | HSBV quartile 4 (Highest) | p for trend | |
|---|---|---|---|---|---|
Age | |||||
≥ 65 years | 1.00 (reference) | 0.81 (0.65–1.02) | 0.79 (0.63–0.99) | 0.59 (0.47–0.75) | < 0.001 |
< 65 years | 1.00 (reference) | 0.90 (0.67–1.20) | 0.94 (0.70–1.25) | 0.79 (0.59–1.05) | 0.119 |
Sex | |||||
Men | 1.00 (reference) | 0.80 (0.63–1.01) | 0.82 (0.65–1.04) | 0.64 (0.52–0.82) | < 0.001 |
Women | 1.00 (reference) | 0.88 (0.67–1.15) | 0.80 (0.60–1.06) | 0.61 (0.45–0.83) | 0.002 |
Race | |||||
White | 1.00 (reference) | 0.69 (0.50–0.95) | 0.66 (0.48–0.92) | 0.60 (0.43–0.84) | 0.002 |
Black | 1.00 (reference) | 0.94 (0.62–1.42) | 0.88 (0.58–1.34) | 0.73 (0.48–1.09) | 0.100 |
Asian | 1.00 (reference) | 1.29 (0.63–2.67) | 2.60 (1.17–5.81) | 1.13 (0.52–2.44) | 0.369 |
Hispanic | 1.00 (reference) | 0.84 (0.58–1.22) | 0.77 (0.53–1.10) | 0.59 (0.41–0.85) | 0.003 |
Other races | 1.00 (reference) | 0.84 (0.55–1.28) | 0.87 (0.57–1.33) | 0.68 (0.45–1.04) | 0.098 |
HTN | |||||
Yes | 1.00 (reference) | 1.05 (0.78–1.42) | 0.96 (0.72–1.29) | 0.75 (0.55–1.01) | 0.039 |
No | 1.00 (reference) | 0.71 (0.57–0.89) | 0.74 (0.59–0.92) | 0.59 (0.47–0.74) | < 0.001 |
DM | |||||
Yes | 1.00 (reference) | 0.87 (0.59–1.29) | 1.06 (0.71–1.58) | 0.74 (0.50–1.10) | 0.228 |
No | 1.00 (reference) | 0.84 (0.69–1.03) | 0.76 (0.62–0.93) | 0.64 (0.52–0.79) | < 0.001 |
CKD | |||||
Yes | 1.00 (reference) | 0.73 (0.35–1.54) | 0.99 (0.48–2.06) | 0.44 (0.22–0.90) | 0.792 |
No | 1.00 (reference) | 0.84 (0.70–1.01) | 0.80 (0.67–0.96) | 0.68 (0.57–0.82) | < 0.001 |
CAD | |||||
Yes | 1.00 (reference) | 0.70 (0.42–1.16) | 0.75 (0.45–1.25) | 0.52 (0.31–0.86) | 0.021 |
No | 1.00 (reference) | 0.84 (0.69–1.01) | 0.82 (0.68–0.99) | 0.67 (0.55–0.81) | < 0.001 |
Comorbidities | |||||
Yes | 1.00 (reference) | 0.94 (0.73–1.21) | 0.94 (0.73–1.22) | 0.67 (0.52–0.87) | 0.003 |
No | 1.00 (reference) | 0.75 (0.58–0.96) | 0.70 (0.54–0.90) | 0.62 (0.48–0.80) | 0.004 |
Admission date | |||||
03/2020–08/2020 | 1.00 (reference) | 0.93 (0.72–1.21) | 0.84 (0.65–1.09) | 0.66 (0.51–0.85) | < 0.001 |
09/2020–02/2021 | 1.00 (reference) | 0.77 (0.58–1.03) | 0.79 (0.59–1.06) | 0.56 (0.41–0.75) | < 0.001 |
03/2021–11/2021 | 1.00 (reference) | 0.67 (0.41–1.10) | 0.78 (0.47–1.31) | 0.86 (0.52–1.42) | 0.755 |
Statin therapy | |||||
Yes | 1.00 (reference) | 0.78 (0.58–1.05) | 0.85 (0.63–1.16) | 0.74 (0.54–0.99) | 0.093 |
No | 1.00 (reference) | 0.85 (0.68–1.06) | 0.81 (0.65–1.01) | 0.62 (0.50–0.78) | < 0.001 |
Anticoagulation | |||||
No | 1.00 (reference) | 2.47 (0.50–12.3) | 0.99 (0.27–3.67) | 0.73 (0.19–2.84) | 0.281 |
Prophylactic | 1.00 (reference) | 1.01 (0.74–1.36) | 0.95 (0.70–1.29) | 0.67 (0.49–0.90) | 0.008 |
Therapeutic | 1.00 (reference) | 0.71 (0.57–0.89) | 0.74 (0.59–0.93) | 0.63 (0.50–0.79) | < 0.001 |
Initial o2 support | |||||
None | 1.00 (reference) | 1.07 (0.62–1.83) | 1.23 (0.68–2.22) | 0.72 (0.42–1.24) | 0.344 |
O2 support other than intubation | 1.00 (reference) | 0.82 (0.67–1.01) | 0.77 (0.63–0.95) | 0.62 (0.50–0.76) | < 0.001 |
Intubated | 1.00 (reference) | 0.26 (0.08–0.78) | 0.29 (0.11–0.78) | 0.36 (0.14–0.94) | 0.101 |
ICU admission | |||||
Yes | 1.00 (reference) | 0.53 (0.37–0.75) | 0.75 (0.53–1.07) | 0.66 (0.47–0.94) | 0.161 |
No | 1.00 (reference) | 0.92 (0.72–1.16) | 0.77 (0.61–0.98) | 0.57 (0.45–0.71) | < 0.001 |