Association of blood viscosity and device-free days among hospitalized patients with COVID-19

Table 3 Association of shear blood viscosity and respiratory organ support-free days up to day 21

	Low-shear BV quartile 1 (Lowest)	Low-shear BV quartile 2	Low-shear BV quartile 3	Low-shear BV quartile 4 (Highest)	p for trend
N	1405	1406	1405	1405
Blood viscosity range (cP)	6.49–9.05	9.05–10.01	10.01–11.29	11.29–25.50
aOR (95% CI)	1.00 (reference)	0.84 (0.70–0.99)	0.80 (0.67–0.960)	0.67 (0.56–0.80)	< 0.001
aOR⁺ (95% CI)	1.00 (reference)	0.88 (0.72–1.07)	0.83 (0.68–1.01)	0.70 (0.57–0.86)	< 0.001
Mean respiratory organ support-free days (standard deviation)	16.7 (8.1)	16.1 (8.6)	15.6 (8.8)	14.9 (9.2)

Linear modeling result: aOR 0.91 (95% CI 0.88–0.95, p < 0.001) per 1 cP increase; aOR 0.82 (95% CI 0.76–0.88, p < 0.001) per IQR (interquartile range, 2.24 cP) increase
Adjusted odds ratios calculated by cumulative logistic regression after adjustments for age, sex, hospital site, race, history of HTN, DM, CKD, and CAD, in-hospital statin use, anticoagulation therapy, date of admission, and measure of initial oxygen support
BV, blood viscosity; cP, centipoise; aHR, adjusted hazard ratio; CI, confidence interval; HTN, hypertension; DM, diabetes mellitus; CKD, chronic kidney disease; CAD, coronary artery disease
⁺ Adjusted odds ratios calculated by cumulative logistic regression after adjustments for age, sex, hospital site, race, history of HTN, DM, CKD, and CAD, in-hospital statin use, anticoagulation therapy, date of admission, measure of initial oxygen support, and initial lab data (white blood cell count, CRP, and D-dimer)

ISSN: 2052-0492