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Table 2 Baseline characteristics according to Hp grouping

From: Potential of cell-free hemoglobin and haptoglobin as prognostic markers in patients with ARDS and treatment with veno-venous ECMO

Characteristic

Mean Hp 0.39 g/l (n = 163)

Mean Hp 0.39 g/l (n = 279)

P value

Mean Hp (g/l)

0.21 [0.13, 0.29]

0.89 [0.60, 1.46]

< 0.001

ICU mortality, n (%)

112 (68.7)

108 (38.7)

< 0.001

ECMO duration (days)

15.00 [5.50, 26.50]

13.00 [7.00, 26.50]

0.601

Age (years)

50.00 [34.00, 60.00]

48.00 [38.00, 61.00]

0.740

Male sex, n (%)

103 (63.2)

181 (64.9)

0.758

Body mass index (kg/m2)

24.69 [21.03, 28.63]

25.77 [22.17, 30.86]

0.045

PBW (kg)

67.75 [58.95, 74.99]

70.46 [59.63, 74.99]

0.233

Charlson comorbity index

3.00 [1.00, 5.00]

2.00 [0.00, 4.00]

0.022

Immunocompromised, n (%)

47 (28.8)

69 (24.7)

0.371

SOFA at ARDS onset

13.00 [10.00, 16.00]

11.00 [8.50, 14.00]

0.004

APACHE at ARDS onset

29.00 [23.50, 36.00]

27.00 [20.00, 33.00]

0.010

SAPS at ARDS onset

61.00 [41.00, 75.50]

55.00 [40.00, 68.00]

0.016

RASS at ARDS onset

-5.00 [-5.00, -4.00]

-5.00 [-5.00, -4.00]

0.725

Pulmonary origin, n (%)

141 (86.5)

254 (91.0)

0.151

ARDS severity, n (%)

  

0.199

 Mild

2 (1.2)

0 (0.0)

 Moderate

11 (6.7)

16 (5.7)

 Severe

150 (92.0)

263 (94.3)

ARDS etiology, n (%)

  

0.001

 Pneumonia

96 (58.9)

209 (74.9)

 Aspiration

24 (14.7)

16 (5.7)

 Other

43 (26.4)

54 (19.4)

ECMO initiation (ICU day)

0.00 [0.00, 1.00]

0.00 [0.00, 0.00]

0.056

Ventilation parameters at ECMO Initiation

PaO2/FiO2 (mmHg)

64.50 [51.62, 85.37]

68.50 [54.80, 86.26]

0.221

PaO2 (mmHg)

63.05 [50.75, 80.80]

66.10 [53.80, 81.00]

0.206

PaCO2 (mmHg)

68.90 [55.30, 83.18]

62.60 [53.50, 82.20]

0.393

pH

7.22 [7.12, 7.29]

7.25 [7.17, 7.34]

0.012

PIP (cmH2O)

40.20 [36.00, 44.27]

39.00 [34.93, 43.00]

0.100

Pplat (cmH2O)

36.07 [33.07, 40.50]

36.00 [32.00, 39.56]

0.440

PEEP (cmH2O)

18.40 [14.82, 21.00]

19.00 [15.00, 21.00]

0.460

Driving pressure (cmH2O)

18.27 [14.65, 21.42]

17.80 [14.00, 21.00]

0.398

Respiratory rate (breaths/min)

24.00 [21.00, 27.20]

25.00 [20.49, 27.67]

0.966

Compliance (ml/cmH2O)

27.20 [19.00, 40.00]

32.83 [21.84, 47.91]

0.027

Tidal volume (ml)

349.73 [241.14, 499.75]

383.30 [297.38, 504.91]

0.144

Septic shock, n (%)

120 (73.6)

158 (56.6)

< 0.001

RRT, n (%)

124 (76.1)

168 (60.2)

0.001

PRBC units transfused (number)

26.00 [15.50, 43.50]

16.00 [8.00, 31.00]

< 0.001

Lactate (mg/dl)

26.00 [11.00, 78.00]

17.00 [11.00, 35.00]

< 0.001

Further rescue therapies, n (%)

   

Inhaled nitric oxide

131 (80.4)

197 (70.6)

0.025

Prone positioning

121 (74.2)

209 (74.9)

0.910

  1. Hp haptoglobin, SOFA sequential organ failure assessment, APACHE acute physiology and chronic health evaluation, SAPS simplified acute physiology score, RASS Richmond Agitation–Sedation Scale, PIP peak inspiratory pressure, Pplat plateau pressure, PEEP positive end-expiratory pressure, RRT renal replacement therapy, PRBC packed red blood cells. Data are expressed as mean (SD), median (25%, 75% quartiles) or frequencies (%), as appropriate