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Table 1 Patient characteristics between patients with and without renal recovery

From: Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study

 

Recovery (n = 100)

Non-recovery (n = 64)

p value

Age (years)

60 (46, 72)

56 (43, 66)

0.259

Male gender

65 (65.0)

37 (57.8)

0.410

Body mass index (kg/m2)

22.9 (20.6, 25.4)

23.9 (20.4, 27.0)

0.162

APACHE II score

13.0 (11, 17)

17 (12, 22)

0.014

Non-renal SOFA score

4 (2, 7)

6 (3, 10)

0.026

Hemoglobin (g/L)

90.0 (82, 102.5)

91.0 (77, 109.0)

0.499

Chronic comorbidities

 Diabetes

18 (18.0)

12 (18.8)

1.000

 Hypertension

33 (33.0)

24 (37.5)

0.615

 COPD

5 (5.0)

3 (4.7)

1.000

 Coronary artery disease

16 (16.0)

7 (10.9)

0.490

 CKD

6 (6.0)

7 (10.9)

0.374

 Chronic liver disease

33 (33.0)

25 (39.1)

0.504

ACEI/ARB

3 (3.0)

6 (9.4)

0.156

Reason for ICU admission

 Surgical

62 (62.0)

50 (78.1)

0.030

 Emergency

24 (24.0)

5 (7.8)

0.008

 Medical

14 (14.0)

9 (14.1)

0.725

Mechanical ventilation

84 (84.0)

51 (79.7)

0.532

PaO2/FiO2

302.5 (192.0, 420.0)

288.3 (204.3, 413.7)

0.562

Sepsis

27 (27.0)

16 (25.0)

0.776

Vasopressors

22 (22.0)

10 (15.6)

0.420

Nephrotoxic drugs use

11 (11.0)

8 (12.5)

0.770

Baseline creatinine(µmol/L)

65.0 (53.9, 76.3)

65.4 (53.0, 76.0)

0.915

Serum creatinine diagnosing AKI (µmol/L)

113.0 (90.9, 144.0)

135.6 (105.1, 205.1)

0.001

eGFRa (mL/min/1.73 m2)

58.6 ± 20.7

46.1 ± 22.9

0.001

UO 24 h after diagnosing AKI (mL/kg/h)

0.42 (0.36, 0.47)

0.27 (0.25, 0.36)

0.002

AKI classification

 Stage 1

73 (73.0)

18 (28.1)

< 0.001

 Stage 2

22 (22.0)

32 (50.0)

 

 Stage 3

5 (5.0)

14 (21.9)

 

Outcomes

 KRT in ICU

9 (9)

19 (30.6)

0.001

 Hospital mortality

12 (12)

13 (20.3)

0.183

 30-Day mortality

11 (11)

11 (17.2)

0.348

  1. Values are median (Q1, Q3), mean ± SD or n (%). Nephrotoxic drug primarily includes vancomycin, aminoglycosides, rifampicin, amphotericin B, immunosuppressants and chemotherapy. aGlomerular filtration rate was estimated by the Modification of Diet in Renal Disease formula
  2. APACHE II Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, ACEI angiotensin-converting enzyme inhibitors, ARB angiotensin receptor blocker, ICU intensive care unit, eGFR estimated glomerular filtration rate, UO urine output, AKI acute kidney injury, KRT kidney replacement therapy