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Table 2 SOFA score, APACHE II score, and in-hospital mortality in patients groups categorized by values of the DIC score and PT-INR

From: Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study

 

Overall

Untreated

Treated

P-value

DIC score ≥ 4 and PT-INR ≥ 1.3

n = 295

n = 139

n = 156

 

 SOFA score 0 h

11 (8–13)

11 (7–12)

11 (8–13)

0.078

 APACHE II score

25 (19–32)

23 (17–29)

27 (20–34)

0.003

 In-hospital mortality, % (freq.)

28.5% (84)

26.6% (37)

29.7% (47)

0.505

DIC score ≥ 4 and PT-INR ≥ 1.4

n = 215

n = 99

n = 116

 

 SOFA score 0 h

11 (8–13)

11 (7–12)

11 (8–13)

0.219

 APACHE II score

26 (20–33)

26 (17–29)

27 (21–34)

0.108

 In-hospital mortality, % (freq.)

32.6% (70)

31.3% (31)

33.6% (39)

0.719

DIC score ≥ 4 and PT-INR ≥ 1.5

n = 143

n = 62

n = 81

 

 SOFA score 0 h

12 (9–14)

12 (10–14)

11 (7–13)

0.829

 APACHE II score

26 (20–33)

26 (19–31)

25 (19–33)

0.961

 In-hospital mortality, % (freq.)

35.7% (51)

41.9% (26)

30.9% (25)

0.171

DIC score ≥ 4 and PT-INR ≥ 1.6

n = 109

n = 49

n = 60

 

 SOFA score 0 h

12 (9–14)

12 (9–13)

11 (8–14)

0.904

 APACHE II score

26 (20–33)

26 (18–30)

27 (21–33)

0.943

 In-hospital mortality, % (freq.)

42.2% (46)

46.9% (23)

38.3% (23)

0.366

DIC score ≥ 5 and PT-INR ≥ 1.3

n = 233

n = 102

n = 131

 

 SOFA score 0 h

11 (8–13)

11 (7–13)

11 (8–13)

0.581

 APACHE II score

26 (19–33)

26 (17–29)

26 (20–34)

0.136

 In-hospital mortality, % (freq.)

31.3% (73)

31.4% (32)

31.3% (41)

0.990

DIC score ≥ 5 and PT-INR ≥ 1.4

n = 177

n = 76

n = 101

 

 SOFA score 0 h

11 (9–14)

11 (7–12)

11 (8–13)

0.667

 APACHE II score

26 (20–33)

26 (17–29)

27 (21–34)

0.431

 In-hospital mortality, % (freq.)

35.0% (62)

35.5% (27)

34.5% (35)

0.904

DIC score ≥ 5 and PT-INR ≥ 1.5

n = 121

n = 49

n = 72

 

 SOFA score 0 h

12 (9–14)

12 (11–14)

11 (8–13)

0.480

 APACHE II score

26 (21–33)

28 (21–33)

26 (20–33)

0.616

 In-hospital mortality, % (freq.)

37.2% (45)

46.9% (23)

30.6% (22)

0.067

DIC score ≥ 5 and PT-INR ≥ 1.6

n = 92

n = 38

n = 54

 

 SOFA score 0 h

12 (9–14)

12 (9–14)

11 (10–13)

0.533

 APACHE II score

27 (22–33)

26 (18–32)

28 (22–33)

0.474

 In-hospital mortality, % (freq.)

43.5% (40)

52.6% (20)

37.0% (20)

0.137

DIC score ≥ 6 and PT-INR ≥ 1.3

n = 140

n = 58

n = 82

 

 SOFA score 0 h

12 (9–14)

11 (7–14)

12 (9–14)

0.970

 APACHE II score

28 (20–34)

25 (17–31)

29 (22–35)

0.239

 In-hospital mortality, % (freq.)

31.4% (44)

34.5% (20)

29.3% (24)

0.513

DIC score ≥ 6 and PT-INR ≥ 1.4

n = 109

n = 45

n = 64

 

 SOFA score 0 h

12 (9–14)

10 (7–14)

12 (9–14)

0.712

 APACHE II score

27 (20–33)

21 (15–30)

29 (23–34)

0.332

 In-hospital mortality, % (freq.)

32.1% (35)

37.8% (17)

28.1% (18)

0.288

DIC score ≥ 6 and PT-INR ≥ 1.5

n = 76

n = 30

n = 46

 

 SOFA score 0 h

13 (10–14)

13 (10–14)

12 (10–14)

0.239

 APACHE II score

28 (22–33)

29 (20–33)

29 (22–33)

0.601

 In-hospital mortality, % (freq.)

32.9% (25)

50.0% (15)

21.7% (10)

0.010

DIC score ≥ 6 and PT-INR ≥ 1.6

n = 61

n = 25

n = 36

 

 SOFA score 0 h

12 (9–14)

11 (9–14)

12 (9–14)

0.195

 APACHE II score

28 (22–33)

28 (18–32)

27 (21–33)

0.154

 In-hospital mortality, % (freq.)

41.0% (25)

56.0% (14)

25.0% (9)

0.014

  1. The P-values shown in this table were obtained by comparing variables between two groups (treated and untreated) using the Mann–Whitney U test
  2. APACHE, Acute Physiology and Chronic Health Evaluation; DIC, disseminated intravascular coagulation; PT-INR, prothrombin time-international normalized ratio; SOFA, Sequential Organ Failure Assessment
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Journal of Intensive Care

ISSN: 2052-0492