Skip to main content

Table 1 Baseline characteristics in sepsis patients according to the PT-INR value

From: Sepsis-related coagulopathy treatment based on the disseminated intravascular coagulation diagnostic criteria: a post-hoc analysis of a prospective multicenter observational study

 

Overall (N = 1,013)

PT-INR ≤ 1.2 (N = 505)

1.2 < PT-INR ≤ 1.4 (N = 265)

1.4 < PT-INR ≤ 1.6 (N = 106)

1.6 < PT-INR (N = 137)

P-value

Patient characteristics

      

 Age, years

72 (63–81)

74 (64–82)

70 (63–79)

72 (62–-82)

72 (62–79)

0.182

 Sex (female/male)

391/622

198/307

100/165

38/68

55/82

0.887

Preexisting conditions

      

 Charlson Comorbidity Index

1 (0–2)

1 (0–2)

1 (0–2)

1 (0–3)

2 (0–3)

0.070

 ADL dependent/independent

223/779

119/386

63/201

17/89

34/103

0.403

Disease severity

      

 APACHE II score

22 (17–29)

21 (16–28)

24 (17–31)a

24 (18–33)a

28 (18–33)a,b

 < 0.001

 SOFA score

9 (6–11)

8 (5–10)

9 (6–12)a

11 (7–13)a,b

11 (7–13)a,b

 < 0.001

 SIRS score

3 (2–4)

3 (2–4)

3 (3–4)

3 (3–4)

3 (2–3)

0.081

 DIC score

4 (2–5)

3 (2–5)

4 (3–6)a

5 (3–6)a,b

5 (2–6)a

 < 0.001

DIC, % (freq.)

50.9 (516)

40.4 (204)

59.2 (157)a

70.8 (75)a,b

58.4 (80)a

 < 0.001

 Septic shock, % (freq.)

62.6 (634)

55.2 (279)

64.9 (172)a

78.3 (83)a,b

73.0 (100)a

 < 0.001

 Blood culture (positive), % (freq.)

58.2 (586)

55.0 (275)

61.9 (164)

61.0 (64)

60.6 (83)

0.223

Primary site of infection, % (freq.)

     

 < 0.001

 Lung

31.3 (317)

35.0 (177)

31.7 (84)

21.7 (23)

24.1 (33)

 

 Abdomen

26.8 (271)

22.8 (115)

28.7 (76)

43.4 (46)

24.8 (34)

 

 Urinary tract

18.6 (188)

20.6 (104)

14.0 (37)

16.0 (17)

21.9 (30)

 

 Skin/soft tissue

7.7 (98)

8.5 (43)

14.0 (37)

5.7 (6)

8.8 (12)

 

 Intravenous catheter

1.7 (17)

2.0 (10)

0.8 (2)

2.8 (3)

1.5 (2)

 

 Bone/joint

1.7 (17)

1.8 (9)

0.8 (2)

0.9 (1)

3.6 (5)

 

 CNS

1.9 (19)

2.4 (12)

2.3 (6)

0.9 (1)

0 (0)

 

 Endocardium

1.4 (14)

1.6 (8)

0.8 (2)

0.9 (1)

2.2 (3)

 

 Implant device

0.6 (6)

0.6 (3)

0 (0)

0.9 (1)

1.5 (2)

 

 Wound

1.2 (12)

1.2 (6)

1.5 (4)

0.9 (1)

0.7 (1)

 

 Others

5.3 (54)

3.6 (18)

5.7 (15)

5.7 (6)

10.9 (15)

 

Therapeutic interventions

      

 Mechanical ventilation, % (freq)

42.4 (422)

38.4 (191)

45.8 (120)

54.9 (56)a

40.7 (55)

0.026

 PMX-DHP, % (freq)

9.1 (89)

7.4 (37)

8.3 (21)a

15.6 (15)a,b

12.0 (16)

 < 0.001

 IVIg, % (freq)

20.5 (201)

13.5 (67)

26.1 (66)a

30.5 (29)a

29.3 (39)a

 < 0.001

 Antithrombin, % (freq)

22.2 (218)

14.3 (71)

25.3 (64)a

38.9 (37)a,b

32.6 (43)a

 < 0.001

 rTM, % (freq)

30.4 (228)

21.1 (87)

38.3 (70)a

61.0 (36)a,b

36.8 (35)a

 < 0.001

 Protease inhibitor, % (freq)

8.1 (79)

7.2 (36)

8.7 (22)a

11.6 (11)a

7.5 (10)a

0.001

 CRRT, % (freq)

27.7 (271)

22.3 (111)

26.6 (67)a

41.7 (40)a,b

39.8 (53)a

 < 0.001

 Corticosteroids, % (freq)

28.9 (296)

24.3 (121)

30.8 (78)a

40.0 (38)a,b

45.0 (59)a

 < 0.001

 Noradrenaline, % (freq)

66.1 (649)

58.7 (294)

70.8 (179)a

78.1 (75)a

76.5 (101)a

 < 0.001

 Enteral nutrition, % (freq)

49.4 (482)

45.5 (235)

52.2 (131)a

45.3 (43)a

55.3 (73)c

 < 0.001

  1. The P-values shown in this table were obtained by comparing variables among four groups (PT-INR ≤ 1.2, 1.2 < PT-INR ≤ 1.4, 1.4 < PT-INR ≤ 1.6, and 1.6 < PT-INR) using the Kruskal–Wallis one-way analysis
  2. SOFA, SIRS, and DIC scores in this table represent those at the time of admission
  3. ADL, activities of daily living; APACHE, Acute Physiology and Chronic Health Evaluation; CNS, central nerve system; CRRT, continuous renal replacement therapy; DIC, disseminated intravascular coagulation; IVIg, intravenous immunoglobulin; JAAM, Japanese Association for Acute Medicine; PMX-DHP, polymyxin B direct hemoperfusion; PT-INR, prothrombin time-international normalized ratio; SIRS, systemic inflammatory response syndrome; SOFA, Sequential Organ Failure Assessment
  4. aP < 0.05 vs. PT-INR ≤ 1.2
  5. bP < 0.05 vs. 1.2 < PT-INR ≤ 1.4
  6. cP < 0.05 vs. 1.4 < PT-INR ≤ 1.6 using the Mann–Whitney U test