Skip to main content

Table 5 Performance of variables for predicting poor 28-day neurological prognosis

From: Predictive value of soluble CD59 for poor 28-day neurological prognosis and all-cause mortality in patients after cardiopulmonary resuscitation: a prospective observatory study

 

Cut-off

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Youden (%)

LR+

LR–

sCD59D1 (ng/mL)

18.71

78.57

68.75

68.7

78.6

47.3

2.51

0.31

sCD59D3 (ng/mL)

23.22

85.71

75.00

75.0

85.7

60.7

3.43

0.19

sCD59D7 (ng/mL)

20.31

85.71

62.50

66.7

83.3

48.2

2.29

0.23

NSED1 (ng/mL)

57.71

50.00

92.86

96.4

32.5

42.8

7.00

0.54

NSED3 (ng/mL)

30.63

65.71

92.86

95.8

52.0

65.7

9.20

0.37

NSED7 (ng/mL)

35.41

55.56

85.71

93.8

52.0

55.6

7.78

0.48

S100βD1 (μg/L)

0.53

57.41

92.86

96.9

36.1

55.6

8.04

0.46

S100βD3 (μg/L)

0.41

68.57

92.86

96.0

54.2

68.6

9.60

0.34

S100βD7 (μg/L)

0.21

81.48

85.71

91.7

70.6

67.2

5.70

0.22

APACHE IID1

21

92.59

64.29

90.9

69.2

56.9

2.59

0.12

APACHE IID3

34

68.57

92.86

96.0

54.2

61.4

9.60

0.34

APACHE IID7

25

85.19

64.29

82.1

69.2

49.5

2.39

0.23

CPR time (min)

9

61.11

92.86

97.1

38.2

53.9

8.56

0.42

sCD59D1 + NSED1

–

85.71

75.00

75.0

85.7

60.7

3.43

0.19

sCD59D3 + NSED3

–

85.71

93.75

92.3

88.2

79.5

13.71

0.15

sCD59D7 + NSED7

–

64.29

93.75

90.0

75.0

64.3

10.29

0.38

sCD59D1 + S100βD1

–

92.86

68.75

72.2

91.7

68.7

2.97

0.10

sCD59D3 + S100βD3

–

92.86

81.25

81.2

92.9

81.3

4.95

0.09

sCD59D7 + S100βD7

–

71.43

93.75

90.9

78.9

71.4

11.43

0.30

sCD59D1 + APACHE IID1

–

78.57

75.00

73.3

80.0

53.6

3.14

0.29

sCD59D3 + APACHE IID3

–

92.86

68.75

72.2

91.7

68.8

2.97

0.10

sCD59D7 + APACHE IID7

–

71.43

93.75

90.9

78.9

65.2

11.43

0.30

  1. APACHE II Acute Physiology and Chronic Health Evaluation, APACHE IID1 APACHE II on day 1 after ROSC, APACHE IID3 APACHE II on day 3 after ROSC, APACHE IID7 APACHE II on day 7 after ROSC, CI confidence interval, CPR cardiopulmonary resuscitation, NSE neuron-specific enolase, NSED1 NSE on day 1 after ROSC, NSED3 NSE on day 3 after ROSC, NSED7 NSE on day 7 after ROSC, ROSC restoration of spontaneous circulation, sCD59 soluble CD59, sCD59D1 sCD59 on day 1 after ROSC, sCD59D3 sCD59 on day 3 after ROSC, sCD59D7 sCD59 on day 7 after ROSC, S100β soluble protein 100β, S100βD1 S100β on day 1 after ROSC, S100βD3 S100β on day 3 after ROSC, S100βD7 S100β on day 7 after ROSC, LR+ positive likelihood ratio, LR– negative likelihood ratio, NPV negative predictive value, PPV positive predictive value