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Table 4 Univariate and multivariate analysis of clinical factors associated with 28-day mortality and day 28 clinical failure in ICU patients with nosocomial pneumonia caused by CR-GNB

From: Clinical effectiveness of tigecycline in combination therapy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective multi-centre observational study

 

28-day mortalitya

Day 28 clinical failureb

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR (95% CI)

P value

aHR (95% CI)

P value

OR (95% CI)

P value

aOR (95% CI)

P value

Age

1.00 (0.99–1.01)

0.843

  

1.01 (1.00–1.02)

0.184

  

Male

0.97 (0.68–1.40)

0.880

  

0.90 (0.60–1.37)

0.636

  

BMI

0.93 (0.90–0.97)

0.001

0.94 (0.90–0.98)

0.006

0.92 (0.88–0.97)

0.001

0.92 (0.88–0.97)

0.002

CRAB

0.95 (0.61–1.47)

0.815

  

1.16 (0.70–1.93)

0.567

2.21 (1.27–3.87)

0.005

Medical ICU

1.27 (0.86–1.89)

0.232

  

1.44 (0.92–2.23)

0.107

  

Malignancies

1.06 (0.64–1.74)

0.830

  

0.79 (0.44–1.41)

0.429

  

Renal insufficiency

1.29 (0.77–2.18)

0.335

  

1.66 (0.85–3.26)

0.137

  

Chronic lung diseases

1.52 (1.02–2.28)

0.042

1.45 (0.96–2.18)

0.075

2.19 (1.29–3.72)

0.004

0.72 (0.46–1.12)

0.146

Diabetes

0.74 (0.51–1.07)

0.109

  

0.69 (0.46–1.05)

0.086

  

APACHE II scorec

1.01 (0.99–1.03)

0.363

  

1.02 (0.99–1.04)

0.263

  

SOFA scored

1.15 (1.10–1.21)

< 0.001

1.17 (1.11–1.24)

< 0.001

1.18 (1.11–1.25)

< 0.001

1.20 (1.11–1.29)

< 0.001

PF ratio ≤ 200e

1.36 (0.94–1.97)

0.100

  

1.44 (0.92–2.24)

0.109

  

Septic shocke

1.60 (1.06–2.41)

0.027

0.73 (0.46–1.18)

0.206

1.82 (1.06–3.13)

0.030

0.73 (0.37–1.44)

0.367

Dialysise

1.62 (1.03–2.55)

0.036

1.00 (0.61–1.64)

0.996

2.12 (1.13–3.99)

0.019

1.39 (0.69–2.84)

0.359

Albumin ≤ 3 mg/dLd

0.99 (0.70–1.39)

0.935

  

0.95 (0.64–1.41)

0.788

  

Sulbactam susceptible

0.96 (0.65–1.43)

0.851

  

0.56 (0.35–0.9)

0.016

1.53 (0.97–2.40)

0.067

Colistin susceptible

1.41 (0.86–2.29)

0.169

  

1.42 (0.85–2.37)

0.179

  

Add-on tigecycline

0.72 (0.50–1.05)

0.086

0.69 (0.47–0.99)

0.047

0.86 (0.57–1.30)

0.474

  
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, CRAB carbapenem-resistant Acinetobacter baumannii, ICU intensive care unit, PF ratio PaO2/FiO2 ratio, SOFA Sequential Organ Failure Assessment
  2. aAdjusted hazard ratio (aHR) and 95% confidence interval (CI) were derived from Cox regression analysis
  3. bAdjusted odds ratio (aOR) and 95% CI were derived from logistic regression analysis
  4. cObtaind on ICU admission date
  5. dObtained on pneumonia index date
  6. ePresence of organ dysfunction on the pneumonia index date
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Journal of Intensive Care

ISSN: 2052-0492