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Table 1 Summary of clinical characteristics of patients enrolled in the study

From: The cardioprotective and anti-inflammatory effect of inhaled nitric oxide during Fontan surgery in patients with single ventricle congenital heart defects: a prospective randomized study

Variable

Group of patients

p

Fontan (n = 49)

Fontan NO (n = 48)

 

Male; n (%)

21 (42.8)

22 (45.8)

0.97

Female; n (%)

28 (57.1)

26 (54.2)

Age in days; mean (SD)

964.6 (228.7)

897.4 (242.4)

0.33

Dominant ventricle; right n (%)

22 (44.9)

20 (41.6)

0.90

Preoperative oxygen saturation (%SO2); mean (SD)

82.4 (12.3)

81.6 (18.4)

0.36

CPB time (min); mean (SD)

98.5 (13.1)

95.6 (18.3)

0.45

Cross-clamp time (min); mean (SD)

33.7 (6.7)

36.5 (8.3)

0.12

Post-CPB Lactate level (mmol/l); median (Q1; Q3)

   

 (5)

5.12 (2.9; 7.9)

3.75 (3.2; 6.5)

0.04

 (6)

2.87 (1.5; 8.2)

3.21 (1.9; 4.0)

0.69

 (7)

5.45 (2.9; 6.7)

4.34 (3.6; 5.1)

0.15

 (8)

3.2 (2.5)

2.6 (3.9)

0.44

 (9)

1.4 (0.8; 2.1)

1.3 (0.4; 0.6)

0.33

Post-CPB glucose level (mmol/l); median (Q1; Q3)

   

 (5)

9.3 (7.8; 11.5)

5.16 (4.1; 5.8)

0.02

 (6)

7.6 (5.2; 12.4)

7.2 (5.9; 8.1)

0.06

 (7)

8.3 (4.4; 12.1)

6.3 (5.1; 8.3)

0.12

 (8)

6.8 (3.6; 9.1)

8.1 (7.3; 9.1)

0.62

 (9)

6.3 (2.6; 7.2)

6.1 (5.2; 7.3)

0.43

HR (beat/min); median (Q1; Q3)

   

 (5)

97.4 (93.2; 110.2)

103.9 (94.9; 114.9)

0.25

 (6)

113.8 (89.5; 130.4)

94.3 (78,3; 105.9)

0.12

 (7)

105.4 (97.1; 131.2)

96.9 (87.2; 113.1)

0.22

 (8)

110.5 (92.5; 126.4)

91.6 (82.5; 112.7)

0.08

 (9)

108.2 (95.9; 124.9)

106.5 (102.1; 109.6)

0.41

BP sys. (mmHg) median (Q1; Q3)

   

 (5)

98.9 (86.6; 110.2)

109.4 (105.8; 110.9)

0.10

 (6)

96.0 (84.5; 102.7)

97.0 (88.4; 118.4)

0.48

 (7)

106.1 (86.6; 119.9)

97.2 (81.7; 105.1)

0.62

 (8)

92.2 (78.8; 111.7)

97.2 (81.7; 105.1)

0.75

 (9)

90.9 (77.2; 116.4)

91.2 (88.1; 92.8)

0.51

BP diast. (mmHg) median (Q1; Q3)

   

 (5)

63.8 (56.6; 65.8)

67.4 (67.1; 68.5)

0.09

 (6)

63.8 (57.7; 73.3)

67.2 (62.6; 70.3)

0.06

 (7)

66.81 (52.8; 66.5)

70.1 (61.9; 76.2)

0.18

 (8)

65.8 (59.8; 66.3)

61.4 (55.7; 64.5)

0.13

 (9)

65.6 (61.7; 68.5)

60.5 (56.3; 62.0)

0.09

CVP / PAP (mmHg) median (Q1; Q3)

   

 (5)

16.2 (14.1; 21.6)

14.2 (9.4; 16.0)

0.04

 (6)

14.3 (10.6; 19.2)

10.9 (9.7; 14.3)

0.03

 (7)

17.11 (11.3; 19.1)

11.3 (8.7; 13.1)

0.03

 (8)

11.9 (8.1; 18.2)

10.1 (8.5; 15.7)

0.15

 (9)

11.5 (8.3; 13.1)

10.9 (8.5; 11.7)

0.70

ICU length of stay (d) median (Q1; Q3)

4.3 (3.4; 7.5)

3.4 (3.2; 5.1)

0.04

Maximal catecholamine index (µg/kg/min); median (Q1; Q3)

5.6 (4.6; 6.8)

3.4 (2.8; 4.1)

0.042

Respiratorysupport time (h); median (Q1; Q3)

13.9 (3.7; 18.5)

9.3 (7.0; 13.2)

0.03

Hospital stay; median (Q1; Q3)

17.2 (9.8; 26.5)

15.6 (12.1; 20.6)

0.44

Postoperative pleural effusions duration (days); median (Q1; Q3)

15.2 (14.2; 21.4)

12.5 (10.5; 17.6)

0.05

  1. Data are presented as mean (SD) or median (Q1:Q3). Timepoint (5) after CPB discontinuation, (6) 4 h after surgery, (7) 8 h after surgery, (8) 12 h after surgery, (9) 24 h after surgery. CPB cardio-pulmonary by-pass, NO nitric oxide, PCICU pediatric cardiac intensive care unit