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Table 1 Characteristics of sepsis hospitalizations with and without multiple sclerosis

From: Association of multiple sclerosis with mortality in sepsis: a population-level analysis

Variables

Multiple sclerosisa

Non-multiple sclerosisa

p value

 

n = 1687

n = 281,338

 

Age, years

  

 < 0.0001

 18–44

227 (13.5)

30,630 (10.9)

 

 45–64

869 (51.5)

90,844 (32.3)

 

 ≥ 65

591 (35.0)

159,864 (56.8)

 

Genderb

   

 Female

1119 (68.3)

128,993 (50.3)

 < 0.0001

Race/ethnicity

  

 < 0.0001

 White

1077 (63.8)

146,142 (51.9)

 

 Hispanic

247 (14.6)

75,235 (26.7)

 

 Black

257 (15.2)

36,783 (13.1)

 

 Other

106 (6.3)

23,116 (8.2)

 

Health insurance

  

 < 0.0001

 Private

507 (30.0)

91,957 (32.7)

 

 Medicare

1001 (59.3)

140,174 (49.8)

 

 Medicaid

133 (7.9)

20,953 (7.4)

 

 Uninsured

34 (2.0)

24,317 (8.6)

 

 Other

12 (0.7)

3592 (1.3)

 

Deyo comorbidity indexc

1.6 (1.7)

2.7 (2.4)

 < 0.0001

Selected comorbidities

   

 Chronic lung disease

343 (20.3)

75,230 (26.7)

 < 0.0001

 Congestive heart failure

242 (14.3)

87,544 (31.1)

 < 0.0001

 Renal disease

265 (15.7)

94,216 (33.5)

 < 0.0001

 Diabetes

436 (25.8)

112,636 (40.0)

 < 0.0001

 Malignancy

84 (5.0)

40,417 (14.4)

 < 0.0001

 Liver disease

53 (3.1)

33,938 (12.1)

 < 0.0001

Site of infection

   

 Respiratory

535 (31.7)

105,601 (37.5)

 < 0.0001

 Urinary

1078 (63.9)

103,365 (36.7)

 < 0.0001

 Abdominal

135 (8.0)

34,813 (12.4)

 < 0.0001

 Skin and soft tissue

114 (6.8)

27,964 (9.9)

 < 0.0001

 Device-related

78 (4.6)

6915 (2.5)

 < 0.0001

 Otherd

106 (6.3)

15,383 (5.5)

0.1509

Septic Shock

990 (58.7)

167,808 (59.6)

0.4526

Number of organ dysfunctionsc

2.3 (1.4)

2.7 (1.5)

 < 0.0001

Type of organ dysfunctions

   

 Respiratory

826 (49.0)

152,684 (54.3)

 < 0.0001

 Cardiovascular

1050 (62.2)

180,694 (64.2)

0.0876

 Renal

781 (46.3)

172,187 (61.2)

 < 0.0001

 Hepatic

56 (3.3)

24,905 (8.9)

 < 0.0001

 Hematological

217 (12.9)

58,772 (20.9)

 < 0.0001

 Neurological

548 (32.5)

778,873 (27.7)

 < 0.0001

ICU admission

788 (46.7)

129,370 (46.0)

0.5652

Mechanical ventilation

505 (29.9)

98,361 (35.0)

 < 0.0001

Hemodialysis

63 (3.7)

35,812 (12.7)

 < 0.0001

Blood transfusion

257 (15.2)

55,891 (19.9)

 < 0.0001

Teaching hospital

401 (23.8)

78,549 (27.9)

 < 0.0001

Hospital disposition

   

 In-hospital death

224 (13.3)

65,213 (23.2)

 < 0.0001

 Hospice

117 (6.9)

22,921 (8.1)

0.0716

 Home

528 (31.3)

100,604 (35.8)

0.0001

 Another acute care hospital

47 (2.8)

10,244 (3.6)

0.0785

 Post-acute care facilitye

764 (45.3)

80,254 (28.5)

 < 0.0001

 Leave against medical advise

7 (0.4)

2102 (0.7)

0.1401

  1. aThe parenthesized figures represent percents, except for Deyo comorbidity index and number of organ dysfunctions; Percentage figures may not add to 100 due to rounding
  2. bGender was missing for 51 (3.0%) hospitalizations with multiple sclerosis arthritis and for 24,943 (8.9%) hospitalizations. without multiple sclerosis; the percent figures for gender in each column refer to that column's denominator for gender
  3. cMean (standard deviation [SD])
  4. dOther sites of infection include endocarditis, blood, genital, bone and joint, and the central nervous system
  5. ePost-acute care facilities include: long-term care hospitals, inpatient rehabilitation, skilled nursing facilities, and nursing homes
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Journal of Intensive Care

ISSN: 2052-0492