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Table 6 Subgroup analysis and sensitivity analysis

From: Intensive care unit versus high-dependency care unit admission on mortality in patients with septic shock: a retrospective cohort study using Japanese claims data

Ā 

30-day mortality

Number of events/ Number of patients (%)e

Overall

ICU

HDU

Adjusted HR

95% CI

P value

Subgroup analysis

Ā Age, years

0.71Ā§

Ā Ā < 65

399/2149 (18.5)

282/1479 (19.0)

117/670 (17.4)

0.92a

0.74ā€“1.13

0.440

Ā Ā 65ā€“74

607/2657 (22.8)

376/1679 (22.3)

231/978 (23.6)

0.83a

0.71ā€“0.98

0.029

Ā Ā 75ā€“84

889/3679 (24.1)

540/2213 (24.4)

349/1466 (23.8)

0.93a

0.82ā€“1.06

0.33

Ā Ā ā‰„ 85

707/2333 (30.3)

378/1213 (31.1)

329/1120 (29.3)

0.92a

0.79ā€“1.06

0.27

Ā Procedures

Ā Ā Mechanical ventilation

1266/4049 (31.2)

896/2986 (30.0)

370/1063 (34.8)

0.95b

0.85ā€“1.07

0.44

Ā Ā CRRT

500/1691 (29.5)

403/1351 (29.8)

97/340 (28.5)

1.08b

0.89ā€“1.33

0.44

Ā Ā PMX

257/1025 (25.0)

180/746 (24.1)

77/279 (27.6)

0.91b

0.7ā€“1.19

0.52

Ā Ā VA-ECMO/IABP

67/200 (33.5)

51/172 (29.6)

16/28 (57.1)

0.35b

0.17ā€“0.69

0.002

Ā Source of infection

Ā Ā Respiratory disease

442/1635 (27.0)

239/971 (24.6)

203/664 (30.5)

0.86b

0.71ā€“1.03

0.1

Ā Ā Urinary tract disease

102/1136 (8.9)

50/526 (9.5)

52/610 (8.5)

1.06b

0.72ā€“1.57

0.75

Ā Ā Gastrointestinal disease

379/1739 (21.7)

278/1293 (21.5)

101/446 (22.6)

1.10b

0.88ā€“1.36

0.38

Ā Ā Hepatobiliary disease

128/848 (15.0)

61/451 (13.5)

67/397 (16.8)

0.68b

0.47ā€“0.99

0.046

Ā Ā Skin/soft tissue

34/174 (19.5)

26/123 (21.1)

8/51 (15.6)

1.63b

0.72ā€“3.71

0.23

Sensitivity analysis

Ā (a) Population which include the patients who met the exclusion criteria

2859/11699 (24.4)

1759/7218 (24.3)

1100/4481 (24.5)

0.9c

0.84ā€“0.97

0.008

Ā (b) ICD-9 codes from the previous study supplemented with the corresponding ICD-10 codes

3204/13816 (23.1)

1965/8448 (23.2)

1239/5368 (23.0)

0.92c

0.86ā€“0.98

0.02

Ā (c) Hospital with ICUs and HDUs

1997/8311 (24.0)

1395/5798 (24.0)

602/2513 (23.9)

0.86c

0.78ā€“0.95

0.002

Ā (d) 14-day mortality

1800/10818 (16.6)

1068/6584 (16.2)

732/4234 (17.2)

0.88c

0.82ā€“0.95

0.002

Ā (e) In-hospital mortality

3308/10818 (30.5)

2041/6584 (31.0)

1267/4234 (29.9)

0.89c

0.83ā€“0.96

0.005

Ā (f) Changing the definition of exposure and comparisond

Ā Ā Ā Ā Ā Ā 

Ā Ā Ā (1)

892/3539 (25.2)

167/671 (24.8)

725/2868 (25.2)

1.02a

0.86ā€“1.21

0.78

Ā Ā Ā (2)

589/2407 (24.4)

167/671 (24.8)

422/1736 (24.3)

0.86a

0.71ā€“1.04

0.14

Ā Ā Ā (3)

1147/4604 (24.9)

725/2868 (25.2)

422/1736 (24.3)

0.88a

0.77ā€“1.00

0.052

Ā (g) Propensity score-matched population

Ā Ā Ā Ā Ā Ā 

Ā Ā Ā (1) Caliper width of 0.1 of SD

1598/6788 (23.5)

746/3394 (21.9)

852/3394 (25.1)

0.89

0.82ā€“0.97

0.013

Ā Ā Ā (2) Caliper width of 0.2 of SD

1765/7432 (23.7)

840/3716 (22.6)

925/3716 (24.8)

0.91

0.84ā€“0.99

0.03

  1. CI confidence interval, SD standard deviation, CRRT continuous renal replacement therapy, PMX-DHP polymyxin B immobilized fiber column direct hemoperfusion, VA-ECMO venoatrial extracorporeal membrane oxygenation, IABP intra-aortic balloon pumping
  2. Ā§P for interaction
  3. aAdjusted for sex, Charlson comorbidity index, admission year, ambulance use, teaching hospitals, emergency charge, hospital beds, patients from nursing home, source of infection, drainage, surgery, mechanical ventilation, CRRT, PMX-DHP, VA-ECMO, use of two or more catecholamines, transfusions (red blood cell, platelet, fresh frozen plasma), albumin, globulin, sedatives drugs, opioids drugs, recombinant thrombomodulin, antithrombin III, and hydrocortisone
  4. bAdjusted for age and the same covariates as a. Among these, procedure and source of infection that fell into each subgroup were excluded from the covariates
  5. cAdjusted for age and the same covariates as a
  6. d(1) ā€œICU management fee 1ā€ vs. ā€œICU management fee 3ā€ and ā€œEmergency and critical care unit management fee 2ā€, (2) ā€œICU management fee 1ā€ vs. ā€œEmergency and critical care unit management fee 1ā€, (3) ā€œICU management fee 3ā€ and ā€œEmergency and critical care unit management fee 2ā€ vs. ā€œEmergency and critical care unit management fee 1ā€
  7. eThe ā€œnumber of eventsā€ indicates deaths within 30Ā days of hospitalization, except for ā€œ14-day mortalityā€, which indicates deaths within 14Ā days