Table 1 Baseline characteristics of patients by the serum albumin change pattern

Demographics

 Age, year

66 (55–75)

63.5 (52.5, 75.3)

70 (61, 77.5)^†

64 (52, 75)

 Male, %

67.9

64.3

66.7

60.3

 BMI, kg/m²

23.6 ± 4.7

24.3 ± 4.2

24.0 ± 4.0

24.0 ± 4.3

Comorbidities

 Diabetes, %

40.8

34.8

42.9

40.3

 Hypertension, %

42.7

39.4

53.2

50.0

 Liver cirrhosis, %

12.2

25.8*

8.7

11.1

 CHF, %

22.5

22.7

34.9

33.3

 COPD %

4.2

6.1

11.9

6.9

 CKD, %

8.9

13.6

19.8

17.4

 Cancer, %

19.1

12.9

21.0^†

11.7

Disease severity

 Sepsis, %

36.2

22.9

18.6^†

6.2

 Anuria, %

59.2

59.3

52.6^†

63.3

 MAP, mmHg

79.1 ± 14.7

80.6 ± 16.6

83.9 ± 18.2

83.2 ± 15.9

 Vasopressors, %

68.2

68.6

60.5^†

49.3

 Ventilator, %

61.1

68.6

60.5

58.9

 SOFA score

11.4 ± 3.7

11.1 ± 3.3

9.9 ± 3.5

9.0 ± 3.4

Laboratory data

 WBC, 10³/μL

14.2 ± 10.9

13.2 ± 11.4

13.5 ± 10.6

13.5 ± 11.8

 Platelet, 10³/μL

136.9 ± 116.5

122.2 ± 86.4*

162.1 ± 99.7

150.3 ± 94.3

 Hemoglobin, g/dL

9.9 ± 5.8

9.6 ± 5.1

11.4 ± 3.2

10.7 ± 2.7

 Total protein, g/dL

5.0 ± 1.1

4.8 ± 0.9

6.1 ± 1.4

5.9 ± 1.1

 Albumin, g/dL

2.5 ± 0.4

2.6 ± 0.3

3.5 ± 0.5^†

3.6 ± 0.5

 BUN, mg/dL

62.5 ± 36.2

54.7 ± 35.3

57.1 ± 38.5

52.4 ± 34.5

 Creatinine, mg/dL

3.5 ± 2.4

3.2 ± 2.5

4.5 ± 8.8

3.2 ± 2.6

 Sodium, mmol/L

136.4 ± 8.2

137.4 ± 7.8

136.5 ± 8.3

137.8 ± 7.7

 Potassium, mmol/L

4.4 ± 0.9

4.3 ± 0.9

5.8 ± 12.4

4.6 ± 1.0

 CRP, mg/L

13.6 ± 11.3

7.7 ± 8.7*

9.3 ± 10.1^†

5.3 ± 7.0

 PT, INR

1.8 ± 1.3

1.8 ± 0.9

1.4 ± 0.4^†

1.8 ± 1.7

CRRT operation

 ICU to RRT, days

1 (0, 4)

1 (1, 6)

1 (0, 2)

0 (0, 1)

 Duration, days

6 (4, 11)

8 (5, 13.3)*

6 (5, 8)

6 (5, 10)

 Delivered dose, ml/kg/h

34.1 ± 5.3

34.9 ± 3.9

33.7 ± 4.9

35.3 ± 5.6

IV albumin infusion,%

15 (5.0)

5 (5.9)

9 (4.6)

8 (3.7)

Reasons for CRRT stop

 Kidney recovery

34.4

37.6

46.7

52.8

 Transition to HD

12.4

21.2*

13.8

17.3

 Unable to maintain CRRT (low BP/DNR/death)

53.2

41.2*

39.5^†

29.9