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Table 1 AUC for aPSS as compared with the PIM2 are shown for PICU mortality

From: Validation of an adapted Pediatric Sepsis Score in children admitted to PICU with invasive infection and sepsis: a retrospective analysis of a Dutch national cohort

Patient category

PICU mortality

Any invasive infectiona (n = 4096)

aPSS: 0.70 (0.67–0.73)

PIM2: 0.74 (0.71–0.77)*

Any invasive infectiona without underlying conditions (n = 1922)

aPSS: 0.81 (0.77–0.86)

PIM2: 0.85 (0.81–0.90)*

Any invasive infectiona with underlying conditions (n = 2174)

aPSS: 0.65 (0.61–0.69)

PIM2: 0.68 (0.65–0.72)*

Sepsisb (n = 1690)

aPSS: 0.71 (0.67–0.76)

PIM2: 0.73 (0.69–0.77)

Sepsisb without underlying conditions (n = 821)

aPSS: 0.83 (0.78–0.89)

PIM2: 0.84 (0.79–0.90)

Sepsisb with underlying conditions (n = 869)

aPSS: 0.65 (0.60–0.71)

PIM2: 0.67 (0.61–0.72)

  1. AUC with the respective 95%-confidence intervals are shown for the primary outcome (PICU mortality)
  2. *p < 0.05 for comparison between aPSS and PIM2
  3. aInvasive infection: meningitis, pneumonia/pneumonitis, peritonitis, necrotizing fasciitis, osteomyelitis, endocarditis, tracheitis, epiglottitis, sepsis, septic shock, or toxic shock as the principal PICU diagnosis or as the first underlying diagnosis
  4. bSepsis: sepsis, septic shock, or toxic shock as the principal PICU diagnosis or as the first underlying diagnosis
  5. a, bANZPIC registry diagnostic codes [5]