From: Optimal timing of introducing mobilization therapy for ICU patients with sepsis
Variable | All patients (n = 296) | Patients in the EM group (n = 96) | Patients in the non-EM group (n = 200) | P-value |
---|---|---|---|---|
Age (year), median [IQR] | 75 [65–81] | 74 [65–81] | 75 [65–81] | 0.90 |
Male sex, n (%) | 200 (68%) | 71 (74%) | 129 (65%) | 0.11 |
BMI (kg/m2), median [IQR] | 21 [18–24] | 22 [19–25] | 21 [18–24] | 0.13 |
Charlson Comorbidity Index, median [IQR] | 2 [1–3] | 2 [1–3] | 2 [1–3] | 0.39 |
APACHE II at ICU admission, median [IQR] | 23 [19–28] | 22 [18–27] | 24 [20–28] | 0.07 |
SOFA score at ICU admission, median [IQR] | ||||
 Total | 8 [5–11] | 7 [5–11] | 9 [6–11] | 0.09 |
 Respiratory | 2 [1–3] | 2 [1–3] | 2 [1–3] | 0.35 |
 Cardiovascular | 3 [0–4] | 3 [0–4] | 4 [0–4] | 0.01 |
 Liver | 0 [0–1] | 0 [0–0] | 0 [0–1] | 0.43 |
 Kidney | 1 [0–2] | 0 [0–2] | 1 [0–2] | 0.46 |
 Coagulation | 1 [0–2] | 1 [0–2] | 1 [0–2] | 0.53 |
 Nervous system | 1 [0–2] | 1 [0–2] | 1 [0–2] | 0.37 |
Main source of the infection, n (%) | ||||
 Abdomen | 132 (45%) | 41 (43%) | 91 (46%) | 0.71 |
 Respiratory tract | 94 (32%) | 37 (39%) | 57 (29%) | 0.09 |
 Urinary tract | 31 (10%) | 8 (8%) | 23 (12%) | 0.54 |
 Soft tissue infection | 24 (8%) | 5 (5%) | 19 (10%) | 0.26 |
 Others or unknown | 15 (5%) | 6 (6%) | 10 (5%) | 0.99 |
Admission to the ICU directly from the ED, n (%) | 233 (79%) | 75 (78%) | 161 (79%) | 0.88 |
Ambulatory dependence before the hospital admission, n (%) | 48 (16%) | 11 (11%) | 37 (19%) | 0.13 |
Septic shock at ICU admission, n (%) | 190 (64%) | 53 (55%) | 137 (69%) | 0.03 |
Patients who received the Maebashi early mobilization protocol, n (%) | 138 (47%) | 92 (96%) | 46 (23%) | < 0.01 |
First intervention day for patients who received rehabilitation intervention during ICU stay (day), median [IQR] | 1.8 [1.0–3.0] | 1.0 [0.8–1.8] | 2.9 [1.7–4.0] | < 0.01 |
First mobilization day for patients who achieved mobilization during ICU stay (day), median [IQR] | 2.8 [1.7–5.1] | 1.9 [1.3–2.4] | 6.0 [4.5–9.0] | < 0.01 |