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Table 1 Population pharmacokinetic model used in the simulations

From: Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study

Parameter Model estimate (RSE (%))
CL (L/h) = θnr + (CrCl/120)θr
θnr 3.5 (9)
θr 2.5 (17)
V1 (L) 20.7 (18)
Q (L/h) 31.9 (22)
V2 (L) 33.5 (13)
IIV_CL (%) 32.7 (21)
IIV_V1 (%) 56.1 (29)
RE_proportional (%) 22.3 (15)
  1. CL clearance, CrCl creatinine clearance, V1 central volume of distribution, Q intercompartmental clearance, V2 peripheral volume of distribution, IIV inter-individual variability, RE residual error, RSE relative standard errors