Skip to main content

Table 1 Population pharmacokinetic model used in the simulations

From: Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study

Parameter

Model estimate (RSE (%))

CL (L/h) = θnr + (CrCl/120)θr

–

θnr

3.5 (9)

θr

2.5 (17)

V1 (L)

20.7 (18)

Q (L/h)

31.9 (22)

V2 (L)

33.5 (13)

IIV_CL (%)

32.7 (21)

IIV_V1 (%)

56.1 (29)

RE_proportional (%)

22.3 (15)

  1. CL clearance, CrCl creatinine clearance, V1 central volume of distribution, Q intercompartmental clearance, V2 peripheral volume of distribution, IIV inter-individual variability, RE residual error, RSE relative standard errors
Back to article page

Journal of Intensive Care

ISSN: 2052-0492