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Table 1 Baseline characteristics of patients before and after the stabilised IPTW using propensity scores

From: Recombinant human soluble thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis: a nationwide observational study

Characteristics All patients Patients after IPTW estimation
mPSL alone group (n = 2602) % rTM group (n = 212) % SMD mPSL alone group (n = 2611) % rTM group (n = 190) % SMD
Male sex 1962 75.4 159 75 − 0.9 1971 75.5 137 72.1 − 7.6
Age, years
 15–70 640 24.6 64 30.2 12.6 655 25.1 54 28.4 8.2
 71–80 1147 44.1 104 49.1 10 1159 44.4 91 47.9 6.7
 ≥ 80 805 30.9 43 20.3 − 24.6 787 30.1 43 22.6 − 17.2
 Missing data 10 0.4 1 0.5 1.3 10 0.4 2 1.1 7.3
Treatment year
 2014 546 21 38 17.9 − 7.7 541 20.7 36 18.9 − 4.6
 2015 566 21.8 60 28.3 15.2 583 22.3 41 21.6 − 1.7
 2016 531 20.4 43 20.3 − 0.3 532 20.4 41 21.6 3.7
 2017 472 18.1 42 19.8 4.3 475 18.2 29 15.3 − 7.6
 2018 487 18.7 29 13.7 − 13.7 482 18.5 42 22.1 9.7
BMI (kg/m2)
 < 23 1282 49.3 105 49.5 0.5 1288 49.3 102 53.7 9.1
 23–25 507 19.5 35 16.5 − 7.8 500 19.1 29 15.3 − 10.2
 ≥ 25 555 21.3 52 24.5 7.6 567 21.7 43 22.6 1.9
 Missing data 258 9.9 20 9.4 − 1.6 257 9.8 16 8.4 − 5.2
Hugh–Jones dyspnoea score upon admission
 1–2 205 7.9 15 7.1 − 3.1 202 7.7 13 6.8 − 3.2
 3 168 6.5 8 3.8 − 12.2 163 6.2 11 5.8 − 2.7
 4 329 12.6 23 10.8 − 5.6 324 12.4 18 9.5 − 9.7
 5 1177 45.2 69 32.5 − 26.2 1154 44.2 85 44.7 0.7
 Missing data 723 27.8 97 45.8 37.9 767 29.4 64 33.7 9
Japan Coma Scale score upon admission
 0- or 1-digit (alert or dull) 2460 94.5 195 92 − 10.2 2463 94.3 180 94.7 2.7
 2-digit (somnolence) 73 2.8 9 4.2 7.8 77 2.9 4 2.1 − 3.8
 3-digit (coma) 69 2.7 8 3.8 6.4 72 2.8 5 2.6 0
Charlson Comorbidity Index
 0 545 20.9 45 21.2 0.7 544 20.8 39 20.5 − 0.2
 1 357 13.7 27 12.7 − 2.9 358 13.7 28 14.7 2.7
 2 510 19.6 34 16 − 9.3 504 19.3 32 16.8 − 5.7
 ≥ 3 303 11.6 21 9.9 − 5.6 302 11.6 20 10.5 − 3.0
Missing data 887 34.1 85 40.1 12.5 904 34.6 70 36.8 4.7
Smoking index, pack-years
 0 1113 42.8 79 37.3 − 11.3 1104 42.3 81 42.6 0.5
 1–39 546 21 50 23.6 6.3 553 21.2 37 19.5 − 4.8
 ≥ 40 618 23.8 51 24.1 0.7 618 23.7 37 19.5 − 10.8
 Missing data 325 12.5 32 15.1 7.6 337 12.9 36 18.9 16.7
ADL upon admission (Barthel Index)
 100 519 19.9 53 25 12.1 526 20.1 33 17.4 − 6.6
 ≤ 95 1612 62 118 55.7 − 12.8 1607 61.5 120 63.2 3.7
 Missing data 471 18.1 41 19.3 3.2 479 18.3 36 18.9 2.0
History of previous hospitalisation
 0 1457 56 110 51.9 − 8.2 1455 55.7 108 56.8 2.4
 1–2 792 30.4 78 36.8 13.5 807 30.9 57 30.0 − 1.9
 ≥ 3 353 13.6 24 11.3 − 6.8 350 13.4 25 13.2 − 0.9
 Academic hospital 2169 83.4 179 84.4 2.9 2179 83.5 164 86.3 7.6
 ICU admission 665 25.6 68 32.1 14.4 683 26.2 55 28.9 6.3
  1. Data were presented as n (%)
  2. BMI body mass index, ADL activities of daily living, ICU intensive care unit, IPTW inverse probability of treatment weighting, mPSL methylprednisolone, rTM recombinant human soluble thrombomodulin, SMD standardised mean difference