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Table 2 Differences of clinical question or recommendation between J-SSCG2020 and SSCG2021

From: New avenues of sepsis research: obtaining perspective by analyzing and comparing SSCG 2021 and J-SSCG 2020



qSOFA score


 Introduce as one of the screening tools

Recommend against using qSOFA as a single screening tool

Adrenaline in patients with sepsis/septic shock


 Suggest against using adrenaline as a second-line vasopressor

Suggest adding adrenaline as the third line agent of vasopressor

Guiding resuscitation


 Suggest using lactate levels as an indicator for initial resuscitation

Suggest guiding resuscitation to decrease serum lactate and capillary refilling time

Renal replacement therapy for hemodynamically unstable patients

 Continuous RRT should be used

No recommendation

Initiation of enteral nutrition


 Suggest initiating at an early period of acute phase (within 24–48 h)

Suggest early (within 72 h) initiation

Vitamin C in septic patients


 Suggest providing vitamin C

Suggest against using IV vitamin C

Mechanical venous thromboembolism prophylaxis


 Suggest using mechanical prophylaxis

Suggest against using mechanical VTE prophylaxis in addition to pharmacological prophylaxis

  1. J-SSCG Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock, SSCG Surviving Sepsis Campaign Guideline, qSOFA quick Sequential Organ Failure Assessment