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Table 2 Differences of clinical question or recommendation between J-SSCG2020 and SSCG2021

From: New avenues of sepsis research: obtaining perspective by analyzing and comparing SSCG 2021 and J-SSCG 2020

J-SSCG2020 SSCG2021
qSOFA score  
 Introduce as one of the screening tools Recommend against using qSOFA as a single screening tool
Adrenaline in patients with sepsis/septic shock  
 Suggest against using adrenaline as a second-line vasopressor Suggest adding adrenaline as the third line agent of vasopressor
Guiding resuscitation  
 Suggest using lactate levels as an indicator for initial resuscitation Suggest guiding resuscitation to decrease serum lactate and capillary refilling time
Renal replacement therapy for hemodynamically unstable patients
 Continuous RRT should be used No recommendation
Initiation of enteral nutrition  
 Suggest initiating at an early period of acute phase (within 24–48 h) Suggest early (within 72 h) initiation
Vitamin C in septic patients  
 Suggest providing vitamin C Suggest against using IV vitamin C
Mechanical venous thromboembolism prophylaxis  
 Suggest using mechanical prophylaxis Suggest against using mechanical VTE prophylaxis in addition to pharmacological prophylaxis
  1. J-SSCG Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock, SSCG Surviving Sepsis Campaign Guideline, qSOFA quick Sequential Organ Failure Assessment