Ultraprotective versus apneic ventilation in acute respiratory distress syndrome patients with extracorporeal membrane oxygenation: a physiological study

Table 2 Physiological data during ultraprotective and apneic ventilation in severe ARDS patients treated with ECMO

	Ultraprotective ventilation	Apneic ventilation	p-values
PEEP [cm H₂O]	15.4 ± 4.8	15.4 ± 4.8	p = 1.000
P_plat [cm H₂O]	27.3 ± 6.4	15.4 ± 4.8	p < 0.001
P_mean [cm H₂O]	20.6 ± 5.0	15.4 ± 4.8	p < 0.001
P_driv [cm H₂O]	11.9 ± 5.8	0.0 ± 0.0	p < 0.001
E_stat,RS [cm H₂O/l]	29.1 ± 18.6	Not applicable
E_stat,L [cm H₂O/l]	22.2 ± 17.9	Not applicable
E_stat,CW [cm H₂O/l]	7.8 ± 3.1	Not applicable
Stress [cm H₂O]	8.2 ± 5.2	− 0.5 ± 3.7	p < 0.001
Mechanical power [joule/min]	12.9 ± 3.8	not applicable
ECMO blood flow [l/min]	4.0 ± 0.8	4.0 ± 0.8	p = 0.783
ECMO gas flow [l/min]	4.0 ± 1.2	4.0 ± 1.1	p = 0.811
PaCO₂ [mmHg]	41.9 ± 6.7	53.8 ± 9.2	p < 0.001
pHa	7.4 ± 0.1	7.3 ± 0.1	p < 0.001
HR (beats/min)	93.0 ± 20.8	93.0 ± 17.6	p = 0.993
MAP [mmHg]	83.3 ± 12.9	83.3 ± 15.1	p = 1.000
CVP [mmHg]	15.8 ± 5.0	15.1 ± 3.1	p = 0.297
Noradrenaline [µg/kg/min]	0.2 ± 0.3	0.2 ± 0.3	p = 0.847
Dobutamine [µg/kg/min]	0.8 ± 2.1	0.8 ± 2.1	p = 0.859

Pooled physiological data from ultraprotective, respectively, apneic ventilation with a FiO₂ of 21%, 50% and 90%
p-values < 0.05 are considered significant (repeated measurement ANOVA followed by Holm-Sidak’s post-hoc test)
Data are presented as mean ± standard deviation
PEEP positive end-expiratory pressure, P_plat plateau airway pressure, P_mean mean airway pressure, P_driv difference between end-inspiratory and end-expiratory tracheal pressure, E_stat,Rs static elastance of the respiratory system, E_stat,L static elastance of the lung, E_stat,Cw static elastance of the chest wall, ECMO extracorporeal membrane oxygenation, PaCO₂ arterial partial pressure of carbon dioxide, pHa arterial pH, HR heart rate, MAP mean arterial pressure, CVP central venous pressure

ISSN: 2052-0492