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Table 2 Physiological data during ultraprotective and apneic ventilation in severe ARDS patients treated with ECMO

From: Ultraprotective versus apneic ventilation in acute respiratory distress syndrome patients with extracorporeal membrane oxygenation: a physiological study

  Ultraprotective ventilation Apneic ventilation p-values
PEEP [cm H2O] 15.4 ± 4.8 15.4 ± 4.8 p = 1.000
Pplat [cm H2O] 27.3 ± 6.4 15.4 ± 4.8 p < 0.001
Pmean [cm H2O] 20.6 ± 5.0 15.4 ± 4.8 p < 0.001
Pdriv [cm H2O] 11.9 ± 5.8 0.0 ± 0.0 p < 0.001
Estat,RS [cm H2O/l] 29.1 ± 18.6 Not applicable  
Estat,L [cm H2O/l] 22.2 ± 17.9 Not applicable  
Estat,CW [cm H2O/l] 7.8 ± 3.1 Not applicable  
Stress [cm H2O] 8.2 ± 5.2 − 0.5 ± 3.7 p < 0.001
Mechanical power [joule/min] 12.9 ± 3.8 not applicable  
ECMO blood flow [l/min] 4.0 ± 0.8 4.0 ± 0.8 p = 0.783
ECMO gas flow [l/min] 4.0 ± 1.2 4.0 ± 1.1 p = 0.811
PaCO2 [mmHg] 41.9 ± 6.7 53.8 ± 9.2 p < 0.001
pHa 7.4 ± 0.1 7.3 ± 0.1 p < 0.001
HR (beats/min) 93.0 ± 20.8 93.0 ± 17.6 p = 0.993
MAP [mmHg] 83.3 ± 12.9 83.3 ± 15.1 p = 1.000
CVP [mmHg] 15.8 ± 5.0 15.1 ± 3.1 p = 0.297
Noradrenaline [µg/kg/min] 0.2 ± 0.3 0.2 ± 0.3 p = 0.847
Dobutamine [µg/kg/min] 0.8 ± 2.1 0.8 ± 2.1 p = 0.859
  1. Pooled physiological data from ultraprotective, respectively, apneic ventilation with a FiO2 of 21%, 50% and 90%
  2. p-values < 0.05 are considered significant (repeated measurement ANOVA followed by Holm-Sidak’s post-hoc test)
  3. Data are presented as mean ± standard deviation
  4. PEEP positive end-expiratory pressure, Pplat plateau airway pressure, Pmean mean airway pressure, Pdriv difference between end-inspiratory and end-expiratory tracheal pressure, Estat,Rs static elastance of the respiratory system, Estat,L static elastance of the lung, Estat,Cw static elastance of the chest wall, ECMO extracorporeal membrane oxygenation, PaCO2 arterial partial pressure of carbon dioxide, pHa arterial pH, HR heart rate, MAP mean arterial pressure, CVP central venous pressure