A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis

Table 1 Patient demographics and characteristics, diagnosis of infection, disease severity and patient outcomes

	Total n=406 episodes, 397 patients
Number of episodes^a
One episode	388 (97.7)
Two episodes	8 (2.0)
Three episodes	1 (0.3)
Demographics^a
Age (years, median (IQR))	74 (64–74)
Sex (male)	236 (59.4)
Department of inclusion
Emergency department	381 (93.8)
Infectious diseases	16 (3.9)
Haemodialysis	9 (2.2)
Comorbidities^a
CCI (median (IQR)	2 (0–2)
Cardiac	90 (22.7)
Hypertension	108 (27.2)
Cerebrovascular disease	48 (12.1)
Chronic pulmonary disease	64 (16.1)
Chronic kidney disease	108 (27.2)
Liver disease	17 (4.3)
Dementia	28 (7.1)
Diabetes	76 (19.1)
Solid malignancies	83 (20.9)
Haematological malignancies	15 (3.8)
Diagnosis of infection
Primary bacteraemia	72 (17.7)
Secondary bacteraemia	127 (31.3)
Bacterial pneumonia	126 (31.0)
Influenza	81 (20.0)
Disease severity*
SOFA (median, IQR))	2 (2–4)
SOFA (1)	73 (18.0)
SOFA (≧2)	333 (82.0)
Septic Shock	4 (1.0)
Bacteraemia	217 (53.4)
Outcome
Length of stay (days, median (IQR))	7 (4–13)
ICU admission	72 (17.7)
ICU length of stay (days, median (IQR))	4 (2–9)
Mortality	44 (10.8)
Worse outcome^#	96 (23.6)

^aDemographics, except department of inclusion, and comorbidities are shown on patient level, not on episode level. *Disease severity based on SOFA score at the start of a new episode. ^#Patients who were admitted to the ICU or who died during hospitalization were classified in the worse outcome group. All variables are presented as number (%) unless otherwise specified

ISSN: 2052-0492