Table 1 Comparison of hemodynamic data before and after esmolol administration in patients with septic shock
Variables | Before treatment | After treatment | P | ||
|---|---|---|---|---|---|
Mean | SD | Mean | SD | ||
CI (L/min/m2) | 4.0 | 0.5 | 3.3 | 0.5 | 0.000 |
SI (mL/m2) | 34.1 | 4.9 | 36.6 | 5.6 | 0.008 |
HR (beats/min) | 116.8 | 10.1 | 90.6 | 4.8 | 0.000 |
MAP (mmHg) | 71.4 | 3.1 | 72.0 | 1.9 | 0.309 |
CVP (mmHg) | 12.4 | 1.5 | 12.8 | 1.7 | 0.273 |
GEDVI (mL/m2) | 748.0 | 25.7 | 751.9 | 25.8 | 0.426 |
ITBVI (mL/m2) | 906.1 | 47.0 | 903.0 | 41.6 | 0.676 |
EVLWI (mL/kg) | 13.3 | 4.7 | 13.4 | 3.9 | 0.888 |
Pcc (mmHg) | 31.4 | 10.9 | 36.7 | 9.4 | 0.008 |
Pmsf (mmHg) | 27.7 | 4.7 | 26.7 | 4.5 | 0.293 |
Slope of VO curve (L/min/mmHg) | 0.109 | 0.040 | 0.104 | 0.044 | 0.511 |
Slope of VR curve (L/min/mmHg) | -0.294 | 0.136 | -0.290 | 0.210 | 0.906 |
Pcc-Pmsf (mmHg) | 4.0 | 12.1 | 10.0 | 10.0 | 0.009 |
Pmsf-CVP (mmHg) | 15.3 | 4.8 | 13.9 | 5.0 | 0.179 |
RIs (mmHg·min·m2/L) | 15.14 | 2.02 | 18.25 | 2.79 | 0.000 |
RIa (mmHg·min·m2/L1) | 10.14 | 2.98 | 10.80 | 3.04 | 0.264 |
RIv (mmHg·min·m2·L−1) | 3.91 | 1.30 | 4.25 | 1.57 | 0.231 |
RIa + RIv (mmHg·min·m2/L1) | 14.05 | 3.51 | 15.05 | 3.40 | 0.145 |
Norepinephrine dosage (μg/kg/min) | 0.20 | 0.05 | 0.20 | 0.04 | 0.444 |
Urine output per hour (mL/kg/h) | 1.40 | 0.49 | 1.45 | 0.54 | 0.589 |