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Table 5 Proportions of ICU patients’ spouses and matched individuals without a history of mental disorders who were prescribed anxiolytics, hypnotics/sedatives, or antidepressants

From: Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study

Period of time ICU patients’ spouses (n = 7248) Matched individuals
(n = 29,423)
Adjusted odds ratio (95% CI) * P value
Anxiolytics and hypnotics/sedatives     
Overall (prescribed within 6 months) 323 (4.5) 1,143 (3.9) 1.16 (1.01–1.32) 0.03
 Index date to 1 month 79 (1.1) 247 (0.8) 1.33 (1.01–1.75) 0.04
 1–2 months 107 (1.5) 310 (1.1) 1.40 (1.11–1.77) 0.004
 2–3 months 106 (1.5) 366 (1.2) 1.15 (0.92–1.45) 0.20
 3–4 months 102 (1.4) 375 (1.3) 1.13 (0.90–1.41) 0.30
 4–5 months 107 (1.5) 360 (1.2) 1.25 (1.00–1.57) 0.05
 5–6 months 105 (1.4) 368 (1.3) 1.25 (1.00–1.57) 0.05
Antidepressants     
Overall (prescribed within 6 months) 27 (0.4) 79 (0.3) 1.39 (0.88–2.18) 0.15
 Index date to 1 month 4 (0.1) 24 (0.1) 0.66 (0.22–1.92) 0.44
 1–2 months 14 (0.2) 33 (0.2) 1.62 (0.86–3.07) 0.14
 2–3 months 14 (0.2) 38 (0.2) 1.34 (0.72–2.50) 0.36
 3–4 months 14 (0.2) 47 (0.2) 1.08 (0.59–1.99) 0.80
 4–5 months 12 (0.2) 46 (0.2) 1.01 (0.52–1.95) 0.98
 5–6 months 14 (0.2) 46 (0.2) 1.30 (0.70–2.41) 0.40
  1. Data are presented as n (%)
  2. ICU intensive care unit; CI confidence interval
  3. *Adjusted for age, sex, status of medical insurance, history of sleep disorders, history of anxiety disorders, history of mood disorders, history of post-traumatic stress disorders, and Charlson comorbidity index score