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Table 5 Proportions of ICU patients’ spouses and matched individuals without a history of mental disorders who were prescribed anxiolytics, hypnotics/sedatives, or antidepressants

From: Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study

Period of time

ICU patients’ spouses (n = 7248)

Matched individuals

(n = 29,423)

Adjusted odds ratio (95% CI) *

P value

Anxiolytics and hypnotics/sedatives

    

Overall (prescribed within 6 months)

323 (4.5)

1,143 (3.9)

1.16 (1.01–1.32)

0.03

 Index date to 1 month

79 (1.1)

247 (0.8)

1.33 (1.01–1.75)

0.04

 1–2 months

107 (1.5)

310 (1.1)

1.40 (1.11–1.77)

0.004

 2–3 months

106 (1.5)

366 (1.2)

1.15 (0.92–1.45)

0.20

 3–4 months

102 (1.4)

375 (1.3)

1.13 (0.90–1.41)

0.30

 4–5 months

107 (1.5)

360 (1.2)

1.25 (1.00–1.57)

0.05

 5–6 months

105 (1.4)

368 (1.3)

1.25 (1.00–1.57)

0.05

Antidepressants

    

Overall (prescribed within 6 months)

27 (0.4)

79 (0.3)

1.39 (0.88–2.18)

0.15

 Index date to 1 month

4 (0.1)

24 (0.1)

0.66 (0.22–1.92)

0.44

 1–2 months

14 (0.2)

33 (0.2)

1.62 (0.86–3.07)

0.14

 2–3 months

14 (0.2)

38 (0.2)

1.34 (0.72–2.50)

0.36

 3–4 months

14 (0.2)

47 (0.2)

1.08 (0.59–1.99)

0.80

 4–5 months

12 (0.2)

46 (0.2)

1.01 (0.52–1.95)

0.98

 5–6 months

14 (0.2)

46 (0.2)

1.30 (0.70–2.41)

0.40

  1. Data are presented as n (%)
  2. ICU intensive care unit; CI confidence interval
  3. *Adjusted for age, sex, status of medical insurance, history of sleep disorders, history of anxiety disorders, history of mood disorders, history of post-traumatic stress disorders, and Charlson comorbidity index score