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Table 3 Proportions of ICU patients’ spouses and matched individuals who were prescribed anxiolytics, hypnotics/sedatives, or antidepressants

From: Association between intensive care unit admission of a patient and mental disorders in the spouse: a retrospective matched-pair cohort study

Period of time ICU patients’ spouses (n = 8490) Matched individuals
(n = 33,946)
Adjusted odds ratio (95% CI) * P value
Anxiolytics and hypnotics/sedatives     
Overall (prescribed within 6 months) 1081 (12.7) 3619 (10.7) 1.19 (1.07–1.32) 0.001
 Index date to 1 month 724 (8.5) 2288 (6.7) 1.32 (1.13–1.54)  < 0.001
 1–2 months 680 (8.0) 2226 (6.6) 1.29 (1.12–1.49) 0.001
 2–3 months 602 (7.1) 2218 (6.5) 1.03 (0.90–1.19) 0.645
 3–4 months 614 (7.2) 2132 (6.3) 1.01 (0.88–1.17) 0.85
 4–5 months 565 (6.7) 2211 (6.0) 1.08 (0.93–1.25) 0.32
 5–6 months 548 (6.5) 2024 (6.0) 1.02 (0.88–1.18) 0.78
Antidepressants     
Overall (prescribed within 6 months) 233 (2.7) 838 (2.5) 1.15 (0.85–1.56) 0.37
 Index date to 1 month 190 (2.2) 700 (2.1) 0.96 (0.61–1.52) 0.86
 1–2 months 181 (2.1) 682 (2.0) 1.22 (0.82–1.83) 0.31
 2–3 months 167 (2.0) 666 (2.0) 1.14 (0.78–1.68) 0.50
 3–4 months 153 (1.8) 650 (1.9) 0.90 (0.61–1.33) 0.60
 4–5 months 148 (1.7) 620 (1.8) 0.95 (0.64–1.40) 0.79
 5–6 months 143 (1.7) 606 (1.8) 0.97 (0.65–1.43) 0.87
  1. Data are presented as n (%)
  2. ICU intensive care unit; CI confidence interval
  3. *Adjusted for age, sex, status of medical insurance, history of sleep disorders, history of anxiety disorders, history of mood disorders, history of post-traumatic stress disorders, and Charlson comorbidity index score