Period of time | ICU patients’ spouses (n = 8490) | Matched individuals (n = 33,946) | Adjusted odds ratio (95% CI) * | P value |
---|---|---|---|---|
Anxiolytics and hypnotics/sedatives | ||||
Overall (prescribed within 6 months) | 1081 (12.7) | 3619 (10.7) | 1.19 (1.07–1.32) | 0.001 |
Index date to 1 month | 724 (8.5) | 2288 (6.7) | 1.32 (1.13–1.54) | < 0.001 |
1–2 months | 680 (8.0) | 2226 (6.6) | 1.29 (1.12–1.49) | 0.001 |
2–3 months | 602 (7.1) | 2218 (6.5) | 1.03 (0.90–1.19) | 0.645 |
3–4 months | 614 (7.2) | 2132 (6.3) | 1.01 (0.88–1.17) | 0.85 |
4–5 months | 565 (6.7) | 2211 (6.0) | 1.08 (0.93–1.25) | 0.32 |
5–6 months | 548 (6.5) | 2024 (6.0) | 1.02 (0.88–1.18) | 0.78 |
Antidepressants | ||||
Overall (prescribed within 6 months) | 233 (2.7) | 838 (2.5) | 1.15 (0.85–1.56) | 0.37 |
Index date to 1 month | 190 (2.2) | 700 (2.1) | 0.96 (0.61–1.52) | 0.86 |
1–2 months | 181 (2.1) | 682 (2.0) | 1.22 (0.82–1.83) | 0.31 |
2–3 months | 167 (2.0) | 666 (2.0) | 1.14 (0.78–1.68) | 0.50 |
3–4 months | 153 (1.8) | 650 (1.9) | 0.90 (0.61–1.33) | 0.60 |
4–5 months | 148 (1.7) | 620 (1.8) | 0.95 (0.64–1.40) | 0.79 |
5–6 months | 143 (1.7) | 606 (1.8) | 0.97 (0.65–1.43) | 0.87 |