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Table 3 Penalized logistic regression cross validation of predictive models

From: Cerebral autoregulation in anoxic brain injury patients treated with targeted temperature management

 

Mortality

Unfavourable outcome

OR (CI)

p value

OR (CI)

p value

Age

1.04 (0.96–1.12)

0.347

1.02 (0.95–1.11)

0.550

Arterial hypertension

3.73 (0.69–20.16)

0.126

3.03 (0.63–14.64)

0.68

Shockable rhythm

0.15 (0.03–0.82)

0.029

0.44 (0.09–2.15)

0.312

Time to ROSC

1.01 (0.92–1.09)

0.909

1.01 (0.93–1.10)

0.809

Cardio-active medications

2.54 (0.47–13.75)

0.279

1.80 (0.37–8.74)

0.463

pCO2 (mmHg)

0.86 (0.72–1.02)

0.088

0.87 (0.73–1.05)

0.156

EEG HMp

16.42 (2.06–130.96)

0.008

10.01 (1.23–81.34)

0.031

Mxa

1.04 (1.01–1.07)

0.011

1.03 (1.01–1.06)

0.049

  1. The fitted models showed an accuracy of 84% (CI 71–93%), a sensitivity of 68% and a specificity of 94% for mortality, and an accuracy of 86% (CI 73–94%), a sensitivity of 100% and a specificity of 50% for unfavourable outcome. CI confidence interval, EEG HMp highly malignant electroencephalography during ICU stay, Mxa mean flow index during normothermia, OR odds ratio, pCO2 arterial carbon dioxide partial pressure during normothermia, ROSC return of spontaneous circulation. Cardio-active medications: noradrenaline (norepinephrine) and/or dobutamine