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Table 2 Clinical and biological variables during the normothermic phase of TTM, according to outcomes

From: Cerebral autoregulation in anoxic brain injury patients treated with targeted temperature management

  Survivors (n = 19) Non-survivors (n = 31) p value FO (n = 14) UO (n = 36) p value
Sedatives, n (%) 6 (31) 19 (61) 0.08 4 (29) 21 (58) 0.11
NMBA, n (%) 1 (5) 7 (23) 0.13 1 (7) 7 (19) 0.41
Mechanical ventilation, n (%) 8 (42) 26 (84) < 0.01 3 (21) 31 (86) < 0.01
MAP, mmHg 77 [70–89] 75 [70–83] 0.47 81 [70–91] 75 [70–85] 0.37
Heart rate, bpm 91 [68–111] 88 [78–103] 0.82 93 [66–108] 88 [78–106] 0.65
Temperature, °C 37.0 [36.8–37.4] 36.8 [36.4–37.1] 0.08 37.1 [37.0–37.5] 36.8 [36.5–37.1] 0.04
Hemoglobin, g/dL 12.2 [10.7–14.0] 10.8 [8.9–12.8] 0.17 11.9 [10.5–14.0] 11.5 [9.3–13.7] 0.68
PEEP, cmH2O 5 [5–8] 6 [5–10] 0.46 5 [5–9] 6 [5–10] 0.51
FiO2 0.4 [0.3–0.5] 0.3 [0.3–0.5] 0.16 0.4 [0.3–0.5] 0.3 [0.3–0.5] 0.25
pH 7.36 [7.32–7.39] 7.40 [7.35–7.42] 0.20 7.38 [7.34–7.39] 7.4 [7.33–7.42] 0.88
PaCO2, mmHg 39 [37–40] 36 [34–40] 0.02 39 [37–42] 37 [34–40] 0.07
PaO2, mmHg 83 [70–92] 80 [72–91] 0.74 85 [76–94] 80 [71–91] 0.43
ScvO2, % 75 [72–79] 75 [73–78] 0.82 75 [72–79] 75 [72–78] 0.83
Lactate, mmol/L 1.3 [1.0–2.0] 1.3 [1.0–2.3] 0.66 1.3 [1.0–1.7] 1.3 [1.0–2.4] 0.37
Time to TCD assessment, hours 38 [35–43] 38 [36–46] 0.78 39 [36–42] 38 [32–48] 0.98
Cardio-active medications, n (%) 9 (47) 23 (74) 0.07 6 (43) 26 (72) 0.10
  1. FiO2 fraction of inspired oxygen, FO favorable outcome, MAP mean arterial pressure, NMBA neuromuscular blocking agents, PEEP positive end-expiratory pressure, PaCO2 carbon dioxide arterial partial pressure, PaO2 oxygen arterial partial pressure, ScvO2 central venous oxygen saturation, TCD transcranial Doppler, UO unfavorable outcome