From: Cerebral autoregulation in anoxic brain injury patients treated with targeted temperature management
 | All (n = 50) | Survivors (n = 19) | Non-Survivors (n = 31) | p value | FO (n = 14) | UO (n = 36) | p value |
---|---|---|---|---|---|---|---|
Male gender, n (%) | 39 (78) | 15 (79) | 24 (77) | 1.00 | 11 (79) | 28 (79) | 1.00 |
Age, years | 65 [55–73] | 60 [51–71] | 67 [55–74] | 0.33 | 58 [51–73] | 66 [57–73] | 0.40 |
APACHE II | 26 [24–31] | 26 [21–28] | 27 [24–33] | 0.07 | 26 [21–28] | 27 [24–32] | 0.17 |
ICU LOS, days | 9 [4–19] | 22 [11–37] | 4 [3–10] | < 0.01 | 18 [9–31] | 6 [3–13] | < 0.01 |
Comorbidities | |||||||
 Arterial hypertension, n (%) | 23 (46) | 7 (37) | 16 (52) | 0.39 | 5 (36) | 18 (50) | 0.53 |
 Vascular disease, n (%) | 10 (20) | 3 (16) | 7 (23) | 0.72 | 3 (21) | 7 (19) | 1.00 |
 Chronic heart failure, n (%) | 3 (6) | 0 (0) | 3 (10) | 0.28 | 0 (0) | 3 (8) | 0.55 |
 Chronic kidney disease, n (%) | 8 (16) | 2 (11) | 6 (19) | 0.69 | 1 (7) | 7 (19) | 0.41 |
 COPD, n (%) | 6 (12) | 2 (11) | 4 (13) | 1.00 | 0 (0) | 6 (17) | 0.17 |
 Diabetes mellitus, n (%) | 10 (20) | 3 (30) | 7 (70) | 0.72 | 1 (7) | 9 (25) | 0.25 |
 Previous Seizure, n (%) | 3 (6) | 0 (0) | 3 (10) | 0.28 | 0 (0) | 3 (8) | 0.55 |
 Minor stroke, n (%) | 7 (14) | 2 (11) | 5 (16) | 0.70 | 1 (7) | 6 (17) | 0.66 |
Cardiac arrest characteristics | |||||||
 Cause of CA, n (%) | |||||||
  Cardiac | 23 (48) | 13 (68) | 10 (32) | 0.02 | 10 (71) | 13 (36) | 0.03 |
  Anoxic | 15 (32) | 2 (11) | 13 (42) | 0.03 | 1 (7) | 14 (39) | 0.04 |
  Obstructive | 2 (6) | 1 (5) | 1 (3) | 1.00 | 1 (7) | 1 (3) | 0.49 |
  Indeterminate | 9 (18) | 4 (22) | 7 (10) | 0.30 | 2 (14) | 8 (26) | 0.30 |
 Shockable rhythm, n (%) | 24 (48) | 14 (58) | 10 (42) |  < 0.01 | 10 (71) | 14 (39) | 0.06 |
 Time to ROSC, min | 20 [10–35] | 16 [10–35] | 23 [16–35] | 0.09 | 13 [10–33] | 22 [16–36] | 0.03 |
Clinical variables and autoregulation assessment | |||||||
 NSE (ng/mL) | 39 [24–78] (n = 32) | 29 [20–40] (n = 14) | 74 [34–108] (n = 18) |  < 0.01 | 25 [20–37] (n = 10) | 56 [32–86] (n = 22) | 0.01 |
 Highly malignant EEG | 18 (36) | 0 (0) | 18 (58) |  < 0.01 | 0 (0) | 18 (50) |  < 0.01 |
 Mxa during HT | 0.33 [0.11–0.58] | 0.37 [0.03–0.51] | 0.31 [0.18–0.65] | 0.25 | 0.21 [0.00–0.46] | 0.38 [0.18–0.65] | 0.08 |
 Mxa during NT | 0.58 [0.30–0.83] | 0.31 [0.00–0.62] | 0.67 [0.46–0.84] | < 0.01 | 0.31 [− 0.01–0.69] | 0.63 [0.43–0.83] | 0.03 |
 Altered CAR at HT, n (%) | 27 (54) | 11 (42) | 17 (52) | 0.77 | 7 (50) | 20 (56) | 0.76 |
 Altered CAR at NT, n (%) | 38 (76) | 10 (53) | 28 (90) | < 0.01 | 7 (50) | 31 (86) | 0.02 |