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Table 1 Demographic and baseline characteristics

From: Adjunctive ketamine for sedation in critically ill mechanically ventilated patients: an active-controlled, pilot, feasibility clinical trial

Variables

All (N = 83)

CG (N = 43)

Ketamine (N = 40)

p

Age, years

61 (44.5–71)

61 (47.5–70)

59 (40.5–73)

0.61

Male, N (%)

51 (61.4)

25 (58.1)

26 (65.0)

0.68

Weight, kg

65 (50.7–73.2)

61.8 (47.5–69.4)

67.5 (51.9–81.2)

0.09

ICU type, N (%)

   

0.74

 Medical

40 (48.2)

19 (44.2)

21 (52.5)

 

 Surgical

22 (26.5)

12 (27.9)

10 (25)

 

 Transplant

21 (25.3)

12 (27.9)

9 (22.5)

 

The primary reason for ICU admission, N (%)

 Sepsis or septic shock

25 (30.1)

14 (32.6)

11 (27.5)

0.79

 Acute respiratory distress syndrome

50 (60.2)

28 (65.1)

22 (55)

0.47

 Cardiovascular

8 (9.64)

3 (6.98)

5 (12.5)

0.47

 Gastrointestinal

6 (7.23)

5 (11.6)

1 (2.5)

0.20

 Neurological

10 (12)

5 (11.6)

5 (12.5)

1

 Trauma

2 (2.41)

1 (2.33)

1 (2.5)

1

Comorbidities, N (%)

 COPD

6 (7.23)

6 (14)

0 (0)

0.03

 Mild liver dysfunction [Child–Pugh score A, B]

9 (10.8)

6 (14)

3 (7.5)

0.49

 Diabetes

28 (33.7)

17 (39.5)

11 (27.5)

0.35

 CKD

16 (19.3)

9 (20.9)

7 (17.5)

0.91

 Solid malignancy

24 (28.9)

14 (32.6)

10 (25)

0.61

 Hematological malignancy

14 (16.9)

4 (9.3)

10 (25)

0.11

 Recipient of solid organ transplantation

21 (25.3)

11 (25.6)

10 (25)

1

 HSCT

7 (8.43)

3 (6.98)

4 (10)

0.71

 HIV/AIDS

1 (1.2)

0 (0)

1 (2.5)

0.48

 Hypertension

24 (28.9)

11 (25.6)

13 (32.5)

0.65

Neuromuscular blockers post-randomization, N (%)

7 (8.43)

2 (4.65)

5 (12.5)

0.25

SOFA score

8 (5–10)

8 (6–9)

8 (5–10)

0.87

APACHE II

20 (13–26)

19 (14–25)

20.5 (13–26.75)

0.83

Lactate at baseline, mmol/L

1.8 (1.2–3.05)

1.4 (1–2.3)

2.2 (1.58–3.4)

0.004

PO2/FiO2 ratio

152 (94.1–294)

144 (88.9–263)

156 (99.2–314)

0.77

PRE-DELIRIC scorea (%)

20 (12–33)

20 (12–36)

20 (13–28)

0.68

Heart rate (HR), beats/min

93 (80–106)

91 (79–105)

93.5 (81.5–106)

0.48

Mean arterial pressure (MAP), mmHg

77 (69–89.5)

77 (69.5–88.5)

76.5 (65.5–91)

0.87

  1. Data presented as n (%), mean ± sd, or median (interquartile range)
  2. APACHE II Acute Physiology and Chronic Health Evaluation II, CKD Chronic kidney disease, CG control group (donates to standard of care), COPD chronic obstructive pulmonary disease, FiO2 fraction of inspired oxygen, HR heart rate, HIV/AIDS human immunodeficiency virus infection and acquired immunodeficiency syndrome, HSCT hematopoietic stem cell transplantation, MAP mean arterial pressure, PaO2 partial pressure of oxygen, PRE-DELIRIC prediction of delirium in ICU patients, SOFA Sequential Organ Failure Assessment
  3. aDelirium prediction model designed for adult critical care patients 24 h after ICU admission and used to predict the factors that may influence delirium risk prior to randomization
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Journal of Intensive Care

ISSN: 2052-0492