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Table 3 The predefined oxygen exposures during study period between the two oxygen regimens among the included studies

From: Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials

Study/year Oxygen exposures (conservative group vs. conventional group)
SpO2 (%) PaO2 (mmHg) PaO2:FiO2 (mmHg) FiO2 (%)
Schjørring et al., 2021 [19] 93 (92–94) vs. 96 (95–97), P <0.05 71 (67–77) vs. 93 (87–99), P <0.05   43 (34–54) vs. 56 (46–71), P <0.05
Barrot et al., 2020 [11] −3.8 (95% CI, −4.3 to −3.2) −28.1 (95% CI, −38.4 to −17.7) NR −15.5 (95% CI, −19.1 to −12.0)
Yang et al., 2018 [13] 95.7±2.3 vs. 98.2±1.8, P<0.001 84 (71–99) vs. 98 (79–116), P=0.060 NR 33 (25–42) vs. 42 (36–50)
Girardis et al., 2016 [8] NR 87 (79–97) vs. 102 (88–116), P<0.001 50±97 vs. 21±102, P=0.15 0.36 (0.30–0.40) vs. 0.39 (0.35–0.42), P<0.001
Panwar et al., 2015 [18] 93.4 (92.9–93.9) vs.97 (96.5–97.5), P <0.001 70 (68–73) vs. 92 (89–96), P <0.001 NR 0.26 (0.25-0.28) vs. 0.36 (0.34-0.39), P<0.001
Asfar et al., 2017 [2] NR P<0.0001 P=0.0039 NR
Mackle et al., 2019 [12] The mean FiO2 and PaO2 during the first 10 days of MV, and the lowest and highest FiO2 and PaO2 values until day 28 were lower in the conservative group
  1. Data expressed as median (IQR) or mean±standard deviation
  2. Abbreviations: FiO2, fraction of inspiratory oxygen; ICU, intensive care unit; MV, mechanical ventilation; NR, not reported; PaO2, partial pressure of arterial oxygen; SpO2, pulse oxygen saturation