Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials

Table 2 Summary of sensitivity analyses of mortality rates of primary outcome

Research periods	Mortality rates of conservative oxygen strategy compared with conventional oxygen strategy
Research periods	All included studies	Studies of patients with severe RF	Studies of patients without severe RF
Longest follow-up	7 RCTs, N=5225; 1.01 (0.94–1.09) [2, 8, 11,12,13, 18, 19]	4 RCTs, N=4143; 0.99 (0.92–1.07) [11, 12, 18, 19]	3 RCTs, N=1082; 1.24 (1.05–1.46) [2, 8, 13]
Stay in ICU	5 RCTs, N=1386; 1.19 (0.89, 1.60) [2, 8, 11, 13, 18]	2 RCTs, N=304; 0.78 (0.55–1.11) [11, 18]	3 RCTs, N=1082; 1.41 (1.17–1.70) [2, 8, 13]
30 days after recruitment	5 RCTs, N=4171; 1.10 (0.90–1.34) [2, 8, 11, 13, 19]	2 RCTs, N=3089; 0.95 (0.85–1.07) [11, 19]	3 RCTs, N=1082; 1.29 (1.07–1.55) [2, 8, 13]
60 days after recruitment	4 RCTs, N=3957; 1.06 (0.90, 1.24) [2, 8, 11, 19]	2 RCTs, N=3089; 0.97 (0.89–1.06) [11, 19]	2 RCTs, N=868; 1.22 (1.02–1.46) [2, 8]
90 days after recruitment	5 RCTs, N=4585; 1.00 (0.93–1.07) [2, 11, 12, 18, 19]	4 RCTs, N=4151; 0.98 (0.91–1.06) [11, 12, 18, 19]	-

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