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Table 2 Summary of sensitivity analyses of mortality rates of primary outcome

From: Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials

Research periods Mortality rates of conservative oxygen strategy compared with conventional oxygen strategy
All included studies Studies of patients with severe RF Studies of patients without severe RF
Longest follow-up 7 RCTs, N=5225; 1.01 (0.94–1.09) [2, 8, 11,12,13, 18, 19] 4 RCTs, N=4143; 0.99 (0.92–1.07) [11, 12, 18, 19] 3 RCTs, N=1082; 1.24 (1.05–1.46) [2, 8, 13]
Stay in ICU 5 RCTs, N=1386; 1.19 (0.89, 1.60) [2, 8, 11, 13, 18] 2 RCTs, N=304; 0.78 (0.55–1.11) [11, 18] 3 RCTs, N=1082; 1.41 (1.17–1.70) [2, 8, 13]
30 days after recruitment 5 RCTs, N=4171; 1.10 (0.90–1.34) [2, 8, 11, 13, 19] 2 RCTs, N=3089; 0.95 (0.85–1.07) [11, 19] 3 RCTs, N=1082; 1.29 (1.07–1.55) [2, 8, 13]
60 days after recruitment 4 RCTs, N=3957; 1.06 (0.90, 1.24) [2, 8, 11, 19] 2 RCTs, N=3089; 0.97 (0.89–1.06) [11, 19] 2 RCTs, N=868; 1.22 (1.02–1.46) [2, 8]
90 days after recruitment 5 RCTs, N=4585; 1.00 (0.93–1.07) [2, 11, 12, 18, 19] 4 RCTs, N=4151; 0.98 (0.91–1.06) [11, 12, 18, 19] -
  1. RF, respiratory failure; ICU, intensive care unit